Specialist Positions - Roybal Lab

Position Overview

The mission of the UCSF Sarcoma Initiative is to support the development of the next generation of cellular therapies to treat this disease. In the Roybal Lab, we engage in translational research in partnership with research groups at UCSF to develop cutting‑edge engineered T cell therapeutics and prepare them for the clinic, as well as develop novel cell technologies for future therapeutic solutions.

We are seeking applications for a Specialist to contribute to early‑stage pre‑clinical development of novel T cell therapeutic circuits for the treatment of Sarcomas. This work will range from proof‑of‑concept studies to IND enabling studies for a phase I clinical trial. This is an excellent opportunity to learn cutting‑edge engineered T cell cancer therapy from leading experts in the field and gain highly sought after pre‑clinical development experience in the field of cell therapy.

• Perform experimental work on protein engineering, primary human T cell culture, viral and non‑viral transductions, and mouse tumor models.
• Develop novel assays.
• Design and validate in‑vitro T cell circuits.
• Establish in‑vivo tumor models.
• Compile pre‑clinical results to support the designation of clinical vector design.
• Contribute to the in‑vitro and in‑vivo pharmacology characterization of therapeutic product candidates in collaboration with a process development team towards an IND filing.
• Work with other staff in the Roybal Lab and collaborators in developing the necessary assays, protocols and SOPs; execute the experimental work, analyze data, and report findings in presentations and progress reports.

• Junior Specialist – Baccalaureate degree (or equivalent) or at least four years of research experience.
• Assistant Specialist – Master’s degree or a baccalaureate degree with 3 or more years of research experience.
• Associate Specialist – Master’s degree (or equivalent) or five to ten years of experience in the relevant specialization.
• Full Specialist – terminal degree (or equivalent) or ten or more years of experience in the relevant specialization.
• Primary immune cell culture.
• Tumor cell culture.
• Flow cytometry.
• Experimental design and data analysis.
• Tumor and T cell injections.
• Tumor growth measurements (bioluminescence or caliper).
• Collection of T cells and tumor cells from mouse blood, tissues, and tumors.

• Multi‑colored flow cytometry and cell sorting experience.
• T cell assay experience (ELISAs, proliferation, cytotoxicity by Incucyte, etc.).
• Human immune cell engineering with viral and non‑viral approaches.
• Experience contributing to translational projects and/or INDs.
• Experience creating and giving data presentations.

Document requirements:

• Curriculum Vitae – CV must clearly list current and/or pending qualifications (e.g., board eligibility/certification, medical licensure, etc.).

Reference requirements:

• 3 required (contact information only).

See Table 24B for the salary range for this position. A reasonable estimate for this position is $55,000 – $194,800.

The University of California is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected status under state or federal law.

UCSF is committed to welcoming and serving all people, honoring the dignity of every individual without preference or prejudice, in support of its public mission and in alignment with our PRIDE values and Principles of Community.

San Francisco, CA