Principal Scientist , Biologics Analytical Research and Development

Abb Vie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people’s lives across several key therapeutic areas including immunology, oncology, neuroscience, and products and services in our Allergan Aesthetics portfolio. For more information about Abb Vie, please visit us at

Abb Vie Biologics Analytical Research & Development (Biologics ARD) is a global analytical sciences organization responsible for CMC analytical development of Abb Vie's pipeline of innovative therapeutic biologic products. Located in a state‑of‑the‑art facility in South San Francisco, the team works collaboratively to advance novel biologic therapeutics—including multi‑specifics, ADCs, antibodies, and novel modalities—into first‑in‑human clinical development and through to clinical proof of concept.

We are seeking a highly skilled analytical scientist to join the Biologics CMC Analytical Research and Development team. This role provides scientific leadership in the development of advanced analytical methods to support biotherapeutic protein characterization, process understanding, and product development. The successful candidate will independently develop innovative approaches, serve as an analytical lead on development teams, contribute to regulatory strategy, and supervise one or more scientists.

• Independently develop state‑of‑the‑art capillary electrophoresis and chromatographic methods to characterize biotherapeutic proteins and their associated variants and impurities.
• Generate new scientific proposals and develop innovative approaches to solve difficult analytical challenges.
• Represent the Biologics CMC Analytical Research and Development Group as Analytical Lead on CMC development teams and as a subject‑matter expert on cross‑functional project teams.
• Supervise a team of one or more scientists and be accountable for their performance.
• Develop, qualify, validate, and transfer fit‑for‑purpose QC release and stability methods; provide technical support and oversight for QC testing at internal and external GMP laboratories.
• Plan, author, and review regulatory submission documents, responses to health‑authority queries, technical reports, laboratory data, and method qualification/validation protocols.
• Engage and influence the broader scientific community through publications, poster, and oral presentations at industry conferences.

• Degree in Chemistry, Biochemistry, Analytical Chemistry, or a related field. PhD with 6+ years, MS with 12+ years, or BS with 14+ years of relevant industry experience.
• Solid understanding of protein chemistry and biochemistry, particularly as it relates to biotherapeutic protein drug development.
• Demonstrated expertise in analytical method development for biologics, with strong hands‑on experience in capillary electrophoresis and HPLC.
• Experience supporting biologics CMC development, QC method qualification/validation, and method transfer.
• Proven ability to interpret complex data, solve technical problems, and propose innovative scientific solutions.
• Experience contributing to regulatory submissions, including quality and characterization sections, and responding to health‑authority questions.
• Strong leadership, communication, and collaboration skills, with experience mentoring and supervising scientists.
• Track record of scientific publications and conference presentations preferred.
• Capacity to work in a fast‑paced, collaborative environment and manage multiple concurrent projects independently.

• Deep understanding of biologics analytics, impurity profiling, and protein characterization.
• Ability to work effectively across functions and influence scientific and technical decisions.
• Strong organizational skills and the ability to manage multiple priorities in a fast‑paced environment.
• Commitment to scientific excellence, quality, and continuous improvement.

This is a full‑time, on‑site role located in South San Francisco, CA. The position requires daily in‑person collaboration across scientific and cross‑functional teams.

Compensation commensurate with experience.

• The compensation range described here is the range of possible base pay that the Company believes in good faith it will pay for this role at the time of posting.
• We offer a comprehensive benefits package including paid time off (vacation, holidays, sick), medical/dental/vision insurance, and 401(k) eligibility.
• This job is eligible to participate in long‑term incentive programs.

Abb Vie is an equal‑opportunity employer and is committed to operating with integrity, driving innovation, transforming lives, and serving our community. Equal Opportunity Employer / Veterans / Disabled.