Post Doc - Immunology

Role:

Your work will contribute to establishing a precision senolytic approach that selectively eliminates pathological senescent cells in the fibrotic lung while sparing healthy tissue.

• Establish and characterize models of cellular senescence relevant to fibrotic lung disease, spanning primary human cells, iPSC-derived cells, and in vivo fibrosis models.
• Identify and validate cell-surface markers that distinguish pathological senescent cells from healthy tissue, prioritizing candidates with a favorable safety profile.
• Develop and engineer immune effector–based strategies to selectively eliminate senescent cells in the fibrotic lung.
• Evaluate senolytic efficacy and its impact on fibrosis across disease-relevant human tissue and in vivo models.
• Collaborate with cross-functional teams and external academic partners, present findings at major scientific conferences, and publish as first author.

• PhD in Immunology, Cell Biology, Molecular Biology, Aging Biology, or a closely related field.
• Demonstrated experience with cellular senescence and at least one of: fibrosis, aging biology, immunology, therapeutic modality engineering (e.g., cell therapy, antibody, or protein engineering), or analytical approaches such as proteomics or single-cell analysis.
• Strong publication record demonstrating scientific productivity and independence.

• Self-directed, motivated, and pursuing research/publication goals.
• Excellent oral/written communication and presentation skills; strong publication record.
• Interest/background in cellular senescence, fibrosis biology, translational drug discovery, and relevant cellular/in vivo models.
• Hands-on immunology/immune cell biology; experience with therapeutic modality development; proteomic/transcriptomic/high-parameter single-cell and imaging approaches; human iPSC culture/directed differentiation; disease-relevant human tissue and/or in vivo fibrosis models; strong multi-modal analytical skills.

• Must be authorized to work in the United States full-time;
  Lilly will not provide sponsorship for visas/work authorization.
• Not permanent; requires US citizenship or permanent resident status; fixed duration of two years (potential to extend to three years, up to four).