Scientist​/Senior Scientist, Structural Cell Biology

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As an individual contributor and Scientist at the Bay Area Institute of Science, you will play a key role in advancing Altos' scientific programs on brain aging and neurodegeneration. Working within the Frost lab, you will be responsible for designing and implementing innovative experimental approaches using electron and light microscopy techniques. This includes developing and utilizing cell types derived from the central nervous system (CNS), applying genetic perturbations to these cells, and employing experimental approaches that include light microscopy and electron microscopy.

The ideal candidate will possess an understanding of CNS cell biology and proficiency in advanced microscopy, image analysis and the biochemical techniques required for electron microscopy. This role reports to Senior Scientist Frank Moss, who reports to Vice President Adam Frost.

• Provide advanced cell culture, and genetic manipulation of iPSC-derived CNS cell types.
• Provide independent design and implementation of all phases of light microscopy experimentation, including experimental design, microscope operation, image capture, and quantitative image analysis.
• Engage with cross-Altos research labs to bridge in vitro with in vivo models and to suggest complementary biochemical and imaging approaches.
• Assist other scientists in the Frost group and beyond in analysis of microscope images using tools such as Zen, Elements, Arivis, Napari, Fiji, or other software. When appropriate, manage image analysis collaborations with the Computer Vision team.
• Prepare samples for cryo-electron microscopy, including single particle and tomographic imaging.

• PhD in a related field, such as Cell Biology, Neuroscience, Genetics
• Thorough understanding of the principles of light microscopy image visualization, analysis, and processing.
• Demonstrable understanding of biochemistry, including the use of electron microscopy for structural biochemistry.
• Excellent communication skills and proven ability to collaborate within a dynamic team.

• Preparation and culturing of iPSC-derived human CNS cell types
• Operation of light microscopes for fixed and live imaging, including confocal and structured illumination microscopes
• Practical experience with the management of terabyte-size microscopy datasets
• Literacy in Fiji/ImageJ, Arivis, Relion, cryoSPARC, MATLAB, R, or Python
• Practical experience with cellular image segmentation and quantitation

• Scientist I, Structural Cell Biology: $148,700 - $190,600
• Scientist II, Structural Cell Biology: $157,200 - $201,500
• Senior Scientist I, Structural Cell Biology: $174,200 - $223,300

Exact compensation may vary based on skills, experience, and location.

We value collaboration and scientific excellence.

We believe that a culture of belonging are foundational to scientific innovation and inquiry. At Altos Labs, exceptional scientists and industry leaders from around the world work together to advance a shared mission. Our intentional focus is on Belonging, so that all employees know that they are valued for their unique perspectives. We are all accountable for sustaining an inclusive environment.

Altos Labs provides equal employment opportunities to all employees and applicants for employment, without regard to race, color, religion, age, sex, national origin, disability status, genetics, protected veteran status, sexual orientation, gender identity or expression, or any other characteristic protected by federal, state or local laws. Altos prohibits unlawful discrimination and harassment. This policy applies to all terms and conditions of…