Director, Health Economics & Outcomes Research

Summary

We are seeking an experienced and strategic Health Economics and Outcomes Research leader to establish and lead the HEOR capability within Medical Affairs, with direct ownership of HEOR and market-access evidence strategy and close partnership on the broader Real-World Evidence (RWE) and registry strategy. The Director, HEOR will be responsible for developing an integrated HEOR and value-evidence strategy for vidofludimus calcium that supports scientific differentiation, clinical development, payer and HTA evidence needs, and launch readiness.

We are seeking an experienced and strategic Health Economics and Outcomes Research leader to establish and lead the HEOR capability within Medical Affairs, with direct ownership of HEOR and market-access evidence strategy and close partnership on the broader Real-World Evidence (RWE) and registry strategy. The Director, HEOR will be responsible for developing an integrated HEOR and value-evidence strategy for vidofludimus calcium that supports scientific differentiation, clinical development, payer and HTA evidence needs, and launch readiness.
This highly cross-functional role sits within Medical Affairs and will partner closely with clinical development, market access, biostatistics, commercial, regulatory, and other functions. The Director will translate clinical, scientific, payer, healthcare-system, and patient evidence needs into a prioritized research roadmap, ensuring that HEOR considerations are incorporated early into development and launch planning.
As one of the company’s first HEOR leaders, this individual will have an opportunity to shape the function from the ground up. The successful candidate will be comfortable building fit-for-purpose infrastructure and governance, directing external research partners, working through ambiguity, and providing clear strategic recommendations in a dynamic, pre-commercial biotechnology environment.

• Develop and maintain a prioritized, multi-year HEOR strategy — in close partnership with the broader RWE and evidence-generation function — aligned with Medical Affairs priorities, clinical-development milestones, the scientific narrative, key MS or payer congress timing, launch timing, and priority markets.
• Lead HEOR-related evidence-gap assessments and translate identified gaps into clear research questions, study concepts, investment recommendations, and decision points.
• Ensure that HEOR evidence plans address the needs of patients, healthcare professionals, payers, HTA bodies, and healthcare systems, and adjust prioritization, timing, and investment as the treatment, evidence, and HTA landscapes evolve.

• Partner on the development and execution of Immunic's real-world evidence strategy — including external MS registry engagement (e.g., MSBase, NARCOMS, national/regional MS registries), commercial real-world data sources (claims, EHR networks), and associated data-use agreements — to generate longitudinal effectiveness, safety, and disease-burden evidence for vidofludimus calcium.
• Help prioritize RWE research questions — such as comparative effectiveness, long-term disability outcomes, treatment persistence, and safety signals — and represent HEOR in relevant MS registry consortia and real-world data networks, building relationships with registry leadership and academic collaborators.

• Design and oversee a portfolio of HEOR and outcomes research — including burden-of-illness, epidemiology, treatment-pattern, patient-reported outcomes/quality-of-life, and economic-modeling studies — along with the budget-impact and cost-effectiveness models that inform payer, reimbursement,…