Scientist II, Assay Operations, Screening Platform Technologies

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS‑addicted cancers. Leveraging its differentiated RAS(ON) tri‑complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer‑driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long‑held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS‑addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

We are seeking a Scientist II, Assay Operations, Screening Platform Technologies (SPT) to support and scale next‑generation cellular screening capabilities for oncology drug discovery. This role will focus on assay operations, screening execution, automation enablement, and assay scale‑up to support high‑throughput and high‑content screening campaigns across early discovery and lead optimisation programs.

The successful candidate will partner closely with cross‑functional collaborators across Discovery Sciences, Cancer Biology, Automation, Data Science, and external partners to establish robust, scalable, and operationally efficient screening workflows. This position is ideal for a scientist with strong experience executing and ope rationalising cellular assays who enjoys working at the intersection of biology, automation, and screening infrastructure.

In this role, you will support the transfer, optimisation, execution, and scaling of cellular assays across multiple screening platforms, helping ensure assays are automation‑ready, reproducible, and fit for high‑throughput applications. You will contribute to the implementation of standardised workflows, assay quality control processes, instrumentation integration, and operational best practices that enable efficient data generation across internal and external screening activities.

The ideal candidate is a highly collaborative and detail‑oriented experimentalist with hands‑on experience in assay operations, liquid handling automation, and screening logistics. They will thrive in a fast‑paced environment, enjoy troubleshooting technical challenges, and contribute to building scalable screening infrastructure that accelerates oncology discovery efforts.

• Optimize, productionalise, validate, and execute robust screening assays across various cellular screening formats (e.g., Cell Titer‑Glo, NanoBRET, imaging‑based, and transcriptomic readouts).
• Lead and support execution of high‑throughput and medium‑throughput screening campaigns using automated liquid handling and integrated instrumentation platforms.
• Coordinate assay transfer activities internally and externally, including protocol standardisation, reagent qualification, documentation, and execution support.
• Develop and implement workflows for quantitative, scalable profiling in support of oncology programmes.
• Contribute to experimental design discussions and data review for projects involving molecular glue characterisation and protein interaction modulation.
• Apply advanced data analysis methods, integrating tools such as Genedata Screener, D360, Spotfire, and programming languages (Python, R) to derive actionable insights from complex assay outputs.
• Coordinate and manage tech transfer to external CROs, ensuring quality execution of high‑throughput screens and phenotypic assays.
• Collaborate within SPT and across functions, Med Chem, Cancer Biology, Bioinformatics, Automation,…