Director, Target Biology

Overview

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline includes RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. RAS(ON) inhibitors include daraxonrasib (RMC-6236), a multi-selective inhibitor; elironrasib (RMC-6291), a G12C-selective inhibitor; zoldonrasib (RMC-9805), a G12D-selective inhibitor; and RMC-5127, a G12V-selective inhibitor, currently in clinical development. The organization seeks new team members who share a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Targets and Mechanisms group within Discovery Biology identifies and characterizes high-priority oncology targets for the tri-complex inhibitor (TCI) platform. The role requires leading the Target Biology team, providing hands-on scientific and people leadership, and collaborating cross-functionally to identify and rapidly assess promising targets, determine hit identification strategy, and advance screening hits through early hit-to-lead discovery. The ideal candidate will be a strategic thinker and accomplished scientist with experience identifying and vetting targets for oncology programs, familiarity with different targeting modalities (including molecular glues), and hands-on hit-to-lead experience.

• Lead a team of scientists focused on target identification, prioritization, and biological validation.
• Work cross-functionally with partners in Medicinal Chemistry, Structural Biology, Discovery Biology, Translational Research, and Cancer Immunology to prioritize oncology targets, implement hit discovery plans, and drive progression from hit identification through lead generation.
• Collaborate with the Translational Research function to apply learnings from clinical and preclinical studies to inform new target identification and prioritization.
• Spearhead innovative approaches and technologies for target discovery and hit identification, specifically for hard-to-drug oncology targets.
• Provide scientific leadership to the team, including technical guidance, coaching, and mentoring.
• Foster a culture of curiosity, scientific rigor, and excellence aligned with Rev Med’s core values and commitment to improving patients’ lives.
• Implement data-driven decision-making processes to prioritize targets and allocate resources effectively.

• PhD in chemical biology, cell-biology, biochemistry, or a related scientific discipline.
• Minimum of 10 years of industry experience, ideally in early-stage drug discovery.
• Experience as a team leader in an industry setting with demonstrated ability to build strong cross-functional relationships and effectively drive early discovery programs.
• Proven problem solver with strong scientific background and expertise in experimental design and data interpretation.
• Excellent communication and decision-making skills.

• Knowledge of molecular glue discovery, cellular models, phenotypic screening, and target identification by chemical labeling.
• Familiarity with multi-omics data, genetic screens (e.g., synthetic lethality) and their application in early discovery.
• Experience applying advanced analytical techniques (e.g., AI and ML) to generate hypotheses from large, multidimensional data sets.
• Project team leadership experience in early-stage discovery programs.
• Experience working with different modalities, such as small molecules, biologics, and molecular glues.

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location.

Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at Rev Med, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and…