Clinical Program Manager

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer‑driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long‑held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor - all in service of patients.

This is a unique opportunity for a Clinical Operations Professional. As a Clinical Program Manager (CPM), you will be responsible for acting as a central contact for the Clinical Study Team(s) and assist with the execution and management of Revolution Medicines (Rev Med) clinical trials.

• Adhere to Clinical Standard Operating Procedures (SOP), Good Clinical Practice (GCP) and International Conference on Harmonization (ICH) Guideline.
• Be a team leader, providing guidance and oversight for the successful management of all aspects of clinical trials within timelines and designated program budgets.
• Partner with cross‑functional teams to manage, adjust, and revise project timelines and budgets as needed
• Analyze data health metrics to be shared with stakeholders.
• Actively partner with cross‑functional teams and vendors to drive the query resolution and data listings review process to meet objectives in a timely and efficient process.
• Conduct risk management, contingency, and scenario planning.
• Supervise, communicate project status/issues, and problem solve to ensure project team goals are met.
• Participate in the development of all study‑related documentation, including study protocols.
• Actively contributes in the selection and management of contract research organizations (CROs) and/or vendors, including development of requests for proposals (RFPs).
• Use all available tools to track, oversee, and communicate on program status to all key stakeholders.
• Participate in other Clinical Operations activities as appropriate.
• Leads a larger, more complex trial with some oversight from senior members of Clinical Operations.
• With minimal support, lead cross‑functional Clinical Study Execution Team (CSETs).
• Participate in and contribute to SOP development, implementation, and training.
• Support junior team members through mentorship.

• RN or Bachelor’s or Masters degree in biological sciences or health‑related field required.
• 8+ years direct Clinical Operations experience in the pharmaceutical or biotech industry, preferably in Clinical Operations or Clinical Research‑related experience. Relevant indirect experiences may also meet the requirement.
• Minimum of 4 years of cross‑functional study management or related leadership experience in life sciences, including multiple years’ experience managing project teams.
• Strong working knowledge of FDA Regulations, ICH Guidelines, and GCP.
• Proven ability to successfully start‑up, manage, and close‑out clinical trials, including authoring clinical study and regulatory documentation and SOPs.
• Experience in selection of CROs/vendors and management of external resources.
• Thrives in a collaborative team setting that demonstrates flexibility required to maintain a fast pace and is driven by a desire to deploy innovative approaches and technologies in a high‑energy environment.
• Be solution‑oriented by anticipating obstacles and difficulties, and…