Principal Scientist - Lead Analytical Research

Salary
: >250,000$ - negotiable for the right candidate

Immune Balance manufactures antibodies for diagnostic and therapeutic use while driving innovation in antibody and protein analysis. Join our dynamic team to advance biotechnology breakthroughs.

We seek a Principal Scientist with 5+ years of biologics antibody sequencing with experience working on 3 or more antibody drugs or biosimilars at top pharma (e.g., Abb Vie, Amgen, Genentech) and proven expertise in making and submitting FDA antibody approval data packages
. This role supports diagnostics and therapeutics manufacturing with advanced analytical skills.

• Sequence antibody heavy/light chains using mass spectrometry (LC-MS/MS, Orbitrap, QTOF) for 100% coverage.
• Perform N-to-C and C-to-N sequencing, resolving leucine/isoleucine and PTMs (e.g., glycosylation).
• Characterize antibodies (disulfide mapping, glycan profiling, heavy/light chain validation) for diagnostic/therapeutic applications.
• Optimize ELISA assays for quantification, affinity, and function.
• Conduct glycan analysis via HILIC-MS or released glycan workflows.
• Analyze MS data with Byonic, Protein Metrics, or PEAKS AB (intact mass ±2 Da).
• Maintain/troubleshoot MS and HPLC/UHPLC systems.
• Collaborate to deliver results for diagnostics and therapeutics
  , including making and submitting FDA antibody approval data packages
  .
• Document experiments for regulatory submissions.

• Education: Ph.D./M.S. in Biochemistry, Analytical Chemistry, or related field (B.S. with 7+ years considered).
• Required Experience: 3+ years of biologics antibody sequencing experience with 3 or more antibody drugs or biosimilars at top pharma (e.g., Abb Vie, Amgen, Genentech).
• Proven expertise in making and submitting FDA antibody approval data packages.
• Expertise in N-to-C/C-to-N sequencing (top-down/bottom-up MS).
• Skilled in PTM analysis, glycan profiling, ELISA development.
• Proficient in MS data tools (Byonic, Max Quant, PEAKS AB).
• Preferred
  
  Skills:
  
  Experience with Maurice, CE-SDS, or iCIEF for FDA characterization.
• Knowledge of FDA/ICH validation guidelines.
• Familiarity with high-throughput proteomics/automation.
• Skills: Strong MS/MS data analysis and problem-solving.
• Detail-oriented, multi-tasking, collaborative.

• Shape diagnostics and therapeutics with cutting-edge tools.
• Apply your expertise in biologics sequencing for 3 or more antibody drugs or biosimilars and FDA data package submissions in a collaborative team.
• Enjoy competitive pay and benefits.

Email resume, cover letter, and project summaries to , emphasizing 5+ years of biologics antibody sequencing experience with 3 or more antibody drugs or biosimilars at top pharma (e.g., Abb Vie, Amgen, Genentech) and experience making and submitting FDA antibody approval data packages
. Applications reviewed on a rolling basis.

Immune Balance is an equal opportunity employer.