Scientist; Multi- Antibody Development

Oxford Biotherapeutics is a clinical-stage biotechnology company focusing on the development of antibody therapeutics for the treatment of cancer. OBT’s OGAP-verify® platform is the world's largest, cancer specific, membrane protein library, directly measuring plasma membrane protein expression in patient tumors. OGAP is used to identify novel, highly tumor specific antigens for novel first-in-class ADC, T-cell Engager (TCE) and Chimeric Antigen Receptor (CAR-T) targets.

Our lead asset, OBT
076, is an Antibody Drug Conjugate (ADC) in Phase 1b clinical development. Our clinical and pre-clinical pipeline of novel biologics is balanced between internal programs, focused on ADCs and checkpoint regulators, and externally partnered programs with key innovators in oncology such as Roche, GSK and Zymeworks.

We areseekinga highly motivated and intellectually curious Scientist to support the discovery and optimization of multi-specific TCEs. The successful candidate will generate high-quality, decision-enabling data across early discovery through IND-enabling studies. This role combines deep hands-on experimental expertise with scientific leadership, assay innovation, and cross-functional collaboration to advance OBT’s multi-specific pipeline.

This role will be filled at the Scientist level.

• Contribute to the design of multi-specific antibodies and oversee their production/purification.

• Design, execute, and lead in vitro functional studies supporting the validation of target combinations, lead selection, and preclinical development of multi-specific TCEs.

• Develop,optimize, andperformfunctional assays to inform potency, selectivity, and safety.(e.g., cytotoxicity, cytokine release, reporter assays).

• Generate and interpret complex datasets with a strong emphasis on scientific rigor, reproducibility, and data quality.

• Builddecision-focuseddata packages and communicate clear scientific conclusions and recommendations to project teams and management.

• Familiarity with diverse antibody platforms and strategies for the design and production of multi-specific antibodies

• Optimize and characterize binding properties of multi-specific antibodies (ELISA, flow cytometry, cell bridging assays)

• Develop and execute multiparameter flow cytometry to assess T-cell activation

• Design and performreal-timecytotoxicity assays (e.g., Incu Cyte, eSight) and other functional readouts relevant to T‑cell engager activity (e.g., reporter assays).

• Design and generate engineered cell systems, including over-expression and CRISPR-based knockout models.

• Isolation and maintenance of primary immune cell populations (e.g., PBMCs, T-cells)

• Collaborate closelyacrossteams toevaluateandoptimizemulti-specific TCEs.

• Coordinate with CROs to deliver high quality, timely data.

• Proactivelyidentifyproject risks, propose mitigation strategies, and communicate progress and challenges clearly to stakeholders.

• Monitor the scientific literature and competitive landscape relevant tomulti-specific TCEs and emerging immuneredirecting modalities.

• Propose innovative experimental approaches to accelerate early-stagediscovery.

• Monitor the scientific literature and competitive landscaperelevant to OGAP-selected targets.

• Foster a culture of scientific rigor, learning, transparency, accountability, and inclusion.

• Contribute scientific expertise and innovative thinking to project teams.

• Adhere to OBT’s Quality Management System (QMS), including SOPs, documentation standards, electronic lab notebooks, and required training.

• Support audit readiness and contribute to continuous improvement of laboratory systems and workflows.

Please note the roles and responsibilities for the position include but are not limited to the above

• Experience supporting the discovery, characterization, and optimization of T-cell engagers, bispecific antibodies or other immune redirecting…