Scientist II, Developability

Scientist II, Develop ability

Department:
Lab Science

Employment Type:

Full Time

Location:

San Mateo, CA

Description

The Role:

Big Hat Biosciences is looking for a hands-on, bench-driven scientist to drive antibody develop ability assessments that advance our Milliner Platform for AI-designed therapeutics. This is a primarily lab-based role where you'll spend the majority of your time at the bench executing and innovating on our develop ability workflows.

* At Big Hat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that

responsibilities and title would adjust as appropriate.

Key Responsibilities

* Lead develop ability R&D projects: design, optimize, and execute high throughput develop ability assays to expand Big Hat's toolkit.

* Drive develop ability assessments (purity, stability, tolerability, biophysical properties) across programs, with strong attention to data interpretation and organization.

* Support late-stage characterization and IND-enabling studies, including formulation screening, stress testing, peptide mapping, and simulated administration studies, to rank and advance lead candidates.

* Serve as the Develop ability lead within project teams, guiding experimental strategy to address liabilities and hit program milestones.

* Work cross-functionally to automate and train colleagues on new and existing methods, build QC frameworks for monitoring assay performance, and adapt workflows to existing LIMS infrastructure.

* Proactively and independently analyze data, interpret scientific findings, propose next steps, and broadcast findings clearly across the organization.

Skills Knowledge and Expertise

* PhD in Biochemistry or relevant discipline with 3+ year(s) of industry experience; exceptional non-PhD candidates with deep bench experience will be considered.

* Strong background in biophysical and analytical characterization of antibodies and antibody fragments: SEC, HIC, CE-SDS, DLS, DSF, ELISA, LC-MS, including method development and optimization.

* Track record of translating complex data into clear results and recommended actions.

* Experience with protein structures and antibody engineering.

* Enthusiastic about learning and onboarding new technologies to expand capabilities and improve work quality, timelines, throughput or cost.

* Nice-to-haves include prior experience working in a dynamic start-up environment, working as a project lead, and working with automation.

Total Rewards

The salary estimated for this position is $145,000 - $165,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

What Big Hat Offers:

* Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)

* Dental, and vision coverage through Guardian

* Additional well-being benefits through Nayya, One Medical, Wagmo, Rula, and more

* 401(k) with company match

* DTO, two weeks of company-wide shutdown, and 12 company holidays

* Paid parental leave