Principal, Machine Learning Scientist

Principal, Machine Learning Scientist

Department: DS/ML (Data Science/Machine Learning)

Employment Type: Full Time

Location: San Mateo, CA

Reporting To: Hunter Elliot

The role: We are seeking a creative, accomplished Principal Machine Learning Scientist to advance the state of the art in ML-driven therapeutic antibody design.

At Big Hat Biosciences, our full-stack antibody drug development platform uses ML to drive every stage from discovery to optimization. Our roboticized high-throughput wet-lab continually adds to our large proprietary datasets, which are piped through a custom LIMS++ data management and orchestration layer to automatically update and deploy the latest models. This makes the development of complex, next-gen therapeutics ‘trivially parallelizable’, at a pace that only accelerates as we develop better ML tooling.

You’re not interested in just git-cloning the latest NeurIPS pub and swapping out the dataset. Motivated by an enthusiasm for the possibility of addressing unmet patient needs and a curiosity about the underlying biology, you’ll apply your world-class ML skillset to refine and expand this state‑of‑the‑art protein engineering platform. Success will mean not only hands‑on methods development, but helping shape the direction for future ML research, and actively participating in the application of our platform to the accelerated design of new therapeutics.

• Design and implement the next state-of-the-art generative models of antibody sequence and structure, and predictive models of antibody properties, trained on proprietary internal datasets of thousands to millions of antibodies.
• Identify opportunities for improvement in our ML tooling, and help to set strategy for ML research, driven by a strong high-level understanding of real-world drug development challenges
• Develop, refine, and deploy de novo design methods for generating initial hits to challenging, therapeutically interesting targets.
• Develop multi-modality, multi-objective iterative protein sequence optimization approaches to lab-in-the-loop antibody design problems for validation and deployment in our high-throughput wet lab – at Big Hat success is only declared upon synthesis of real antibodies with drug-like properties.
• Maintain an in-depth understanding of the current state-of-the-art in ML-driven protein engineering, both in the literature and at Big Hat.
• Share your findings at top-tier conferences and publish in leading scientific journals to advance the field of protein engineering.
• Provide technical guidance and mentorship to other ML and data science FTEs and interns.
• Provide ML expertise and support for ongoing therapeutics programs, directly contributing to the development of new drugs.
• Collaborate with our engineering team to ensure maximal efficiency in the automated deployment of our latest models to ongoing drug development programs.
• Work closely with an interdisciplinary team of drug developers, wet lab scientists, automation specialists, data scientists, etc. to identify inefficiencies or potential improvements in Big Hat’s platform, and plan and prioritize ML methods development accordingly.

• PhD in ML/CS or in the hard sciences with 5+ years experience developing and applying novel ML methods and a strong quantitative background.
• Publications in major ML conferences and/or leading journals, or extensive demonstrable track record developing and applying novel ML in industry.
• Strong competency in Python, familiarity with PyTorch, and experience with modern software engineering best practices.
• Excellent communication skills, sufficient biomedical domain knowledge to interact effectively with diverse scientific teams.
• Enjoys a fast-paced environment and excels at executing across multiple projects.
• Familiarity with the current state-of-the-art in ML-driven protein engineering
• Nice-to-haves include experience with de novo design, NGS data, Bayesian optimization, familiarity with antibody biology and drug development, and experience training and deploying models on AWS.

The salary estimated for this position is $233,000 - $266,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.

What Big Hat Offers:

• Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
• Dental, and vision coverage through Guardian
• Additional well-being benefits through Nayya, One Medical, Wagmo, Rula, and more
• 401(k) with company match
• DTO, two weeks of company-wide shutdown, and 12 company holidays
• Paid parental leave