Senior Research Associate, Discovery Medicine
Listed on 2026-08-05
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Research/Development
Immunology Research, Research Scientist
Senior Research Associate, Discovery Medicine
Big Hat Bioscience is looking for a motivated and energetic Senior Research Associate with a strong background in Immunology, cell culture, flow cytometry and primary cell-based assays to support the characterization of our lead therapeutic candidates. At Big Hat we believe in titles that commensurate with skill set, relative organizational impact, and value contribution; more experienced candidates are encouraged to apply, with the understanding that responsibilities and title would adjust as appropriate.
Key Responsibilities- Drive the development of therapeutics by owning the functional characterization of therapeutic candidates.
- Plan, execute, and analyze TDCC, T cell activation, cytokine release, FACS, ELISA, ADCC, and other relevant functional assays.
- Perform isolation and culture of primary immune cells from blood or tissue.
- Inform program plans based upon experimental results and make relevant recommendations for program conceptualization and advancement.
- Keep detailed and organized records of experimental protocols and results.
- Proactively and independently interpret and present scientific findings.
- Collaborate and communicate across a diverse research team to successfully progress scientific goals.
- B.Sc. degree in cell biology, molecular biology, biochemistry, genetics, immunology, or a related field, with at least 3 years of relevant experience, including 1 year in industry.
- Hands-on proficiency in standard immunology and cell biology techniques such as mammalian cell culture and multicolor flow cytometry.
- Previous experience with automation and high-throughput assays desired.
- Scientific curiosity and problem-solving abilities.
- A strong can-do mentality and desire to thrive in a dynamic start-up environment.
- The ability to communicate clearly and build open collaborative relationships.
The salary estimated for this position is $100,000 - $115,000 + bonus + options + benefits. Compensation will vary depending on job-related knowledge, skills, and experience. Actual compensation will be confirmed in writing at the time of the offer.
What Big Hat Offers:
- Range of health insurance plan options through Anthem and Kaiser (monthly credit if benefit waived)
- Dental, and vision coverage through Guardian
- Additional well-being benefits through Nayya, One Medical, Wagmo, Rula, and more
- 401(k) with company match
- DTO, two weeks of company-wide shutdown, and 12 company holidays
- Paid parental leave
Big Hat Biosciences designs safer, more effective biologic therapies for patients using machine learning and synthetic biology. Big Hat integrates a wet lab for high-speed characterization with machine learning technologies to guide the search for better antibodies. We apply these design capabilities to develop new generations of safer and more effective treatments for patients suffering from today's most challenging diseases. Big Hat is a Series B biotech outside San Francisco with a team-oriented, inclusive, and family-friendly culture.
Our broad pipeline of wholly-owned and partnered therapeutic programs span many disparate indications with high unmet need, such as cancer, inflammation, and infectious disease. Big Hat has raised >$100M from top investors, including Section 32, a16z, and 8VC.
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