CW Research Associate; TEMPORARY

Overview

Bio Marin is a global biotechnology company that relentlessly pursues bold science to translate genetic discoveries into new medicines that advance the future of human health. Since 1997, Bio Marin has applied scientific expertise to understand the underlying causes of genetic conditions to create transformative medicines across multiple treatment modalities. Bio Marin’s Worldwide Research and Development (WWRD) spans from research and discovery to post-market clinical development, supporting first-in-class and best-in-class therapeutics that meaningfully advance patients with genetic diseases.

Contract 1 year
• On-site in San Rafael
• Five Days per Week

The Therapeutics Process Development & Characterization (TPDC) group is seeking a highly motivated temporary Research Associate I/II to support biologics purification and analytical characterization, with a primary focus on enzymes and exposure to other therapeutic proteins, antibodies, and peptide-based modalities. This is a laboratory-based role involving hands-on purification and characterization of biologics using established chromatography and filtration workflows. The successful candidate will support multiple early-stage and exploratory research programs across Bio Marin.

Occasional responsibilities may include basic instrument and equipment maintenance in support of laboratory operations. The ideal candidate is detail-oriented, organized, and able to work independently with guidance in a fast-paced research environment.

• Protein & Biologic Purification:
  Perform purification of recombinant enzymes and other therapeutic biologics (proteins, antibodies, peptides) using standard chromatography systems (e.g., AKTA Pure, AKTA Avant).
• Execute purification workflows, including:
• o Affinity chromatography
• o Ion exchange chromatography (AEX/CEX)
• o Size-exclusion chromatography (SEC)
• o Hydrophobic interaction chromatography (HIC)
• o Desalting and buffer exchange
• Concentration and buffer exchange using tangential-flow filtration (TFF) or centrifugal filtration
• Prepare buffers and reagents according to established protocols
• Support routine equipment checks, basic instrument maintenance, and troubleshooting as needed

• Analytical Characterization:
  Perform analytical assays to assess purity, identity, and concentration of biologics (e.g., SDS-PAGE, CE-SDS, SEC-HPLC, RP-HPLC, UV/Vis spectrophotometry) and other established protein or peptide analytical methods as required
• Execute established methods with emphasis on data quality, reproducibility, and documentation
• Assist with basic data analysis and communication of results to project teams

• Maintain accurate and complete electronic and/or paper laboratory notebooks
• Follow established SOPs and document deviations with guidance
• Communicate results, observations, and progress updates clearly within the team
• Contribute to a safe, clean, and well-organized laboratory environment in compliance with Bio Marin safety standards

• Research Associate I:
  Bachelor’s degree in Biochemistry, Biology, Chemical Engineering, or related discipline; 0-2 years of relevant hands-on laboratory experience
• Research Associate II:
  Bachelor’s degree with 2+ years of relevant experience, or Master’s degree with 1-2 years of relevant experience; prior biologics purification experience strongly preferred; experience with FPLC/HPLC and common protein analytical techniques is desirable

• Familiarity with AKTA Pure/Avant or similar chromatography instrumentation
• Strong attention to detail, organization, and reliable documentation
• Ability to follow established workflows and troubleshoot with guidance
• Effective communication and collaboration skills
• Working knowledge of Microsoft Office; familiarity with data analysis tools (e.g., Graph Pad Prism, JMP) is a plus

Note:

This description is not intended to be all-inclusive, or a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assigned.

Equal Opportunity Employer/Veterans/Disabled. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

In the U.S., the salary range for this position is $31 to $50 per hour. The base pay offered will consider internal equity and may vary by geographic region, job-related knowledge, skills, and experience. This position may be eligible for discretionary bonuses, stock-based incentives, paid time off, and a benefits package including medical, dental, vision, and life insurance. For additional benefits information, visit:

• Eligible employees may participate in benefit plans, subject to terms and conditions