Scientist II, Oligonucleotides

Scientist II, Bioconjugation Chemist

Bio Marin is seeking a dedicated and skilled Scientist II specializing in bioconjugation chemistry to contribute to our cutting-edge research and development efforts in nucleic acid-based therapeutics. The successful candidate will be responsible for designing and synthesizing bioconjugates, including antibody-drug conjugates (ADCs), antibody-oligo conjugates (AOCs), and other complex biomolecules. This role requires a strong background in organic chemistry, bioconjugation techniques, and analytical characterization methods.

This role offers a unique opportunity to be part of a dynamic team at the forefront of biotechnology innovation, working on projects that have the potential to transform patient outcomes.

Key Responsibilities:

• Engage actively in project team discussions across the organization, providing subject matter expertise to support the progression of research projects and the development of new methodologies.
• Work synergistically with multidisciplinary teams, including bioconjugation specialists, chemists, and biologists, to drive project success and foster a collaborative research environment.
• Design and synthesize bioconjugates such as antibody-oligo conjugates (AOCs), peptide conjugates, and other complex biomolecules.
• Develop and optimize conjugation methodologies and purification processes.
• Characterize bioconjugates using various analytical techniques, including HPLC, LC-MS, SDS-PAGE, and spectroscopy.
• Collaborate with cross-functional teams, including Biology, Pharmacology, and Process Development, to support preclinical and clinical programs.
• Maintain accurate and detailed laboratory records and documentation.
• Present research findings to internal teams and at scientific meetings.
• Stay up-to-date with the latest advancements in bioconjugation chemistry and related fields.

Qualifications:

• Ph.D. in Chemistry, Biochemistry, or a related field with a focus on bioconjugation techniques and organic synthesis.
• Minimum of 3-5 years of postdoctoral experience or industry experience in bioconjugation chemistry.
• Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.
• Proven track record in designing and synthesizing bioconjugates, including AOCs and peptide conjugates.
• Strong knowledge of analytical techniques for characterizing bioconjugates.
• Excellent problem-solving skills and the ability to work independently and collaboratively.
• Strong written and verbal communication skills.

Why Join Bio Marin?

• Opportunity to work on cutting-edge biopharmaceuticals that make a meaningful impact on patients' lives.
• Collaborative and innovative work environment.
• Comprehensive benefits package, including health insurance, 401(k) matching, and professional development opportunities.
• Located in the beautiful San Francisco Bay Area with access to a vibrant scientific community.

Skills:

• Demonstrated ability to work independently as well as part of a collaborative team environment, with a proactive approach to problem-solving and advancing research programs.
• Strong enthusiasm for scientific research and innovation, coupled with excellent organizational skills and the ability to manage multiple tasks and projects simultaneously.
• Commitment to maintaining up-to-date knowledge of advancements in oligonucleotide chemistry and related fields, with a willingness to engage in ongoing professional development.
• Expertise in solid-phase oligonucleotide synthesis and purification, with a strong track record of successful project outcomes.
• Excellent written and verbal communication skills, with the ability to effectively present data and findings to both technical and non-technical audiences.

Work Style:

• This is an onsite daily role in San Rafael, CA.
• This role will have a daily presence in our Research labs executing experiments.
• This position represents an exciting opportunity to contribute to Bio Marin's mission of developing innovative therapies for patients with serious and life-threatening conditions. We look forward to welcoming a passionate and skilled oligonucleotide chemist to our team.