Medical Director, Experimental Medicine

Fully remote role, US based candidates only. Bio Marin’s Experimental Medicine team is seeking a physician scientist to serve as a key matrixed clinical leader focused on preclinical planning, execution, and design of first-in-human clinical experiments. Leveraging deep experience in biomarkers and translational clinical research, the Medical Director will partner with Preclinical Pharmacology, Biology, Clinical Pharmacology, Preclinical Safety, Clinical Safety, Regulatory and Clinical Operations colleagues to ensure that Bio Marin assets are optimally positioned at the time of IND filing to inform a well‑designed clinical strategy.

The Medical Director will have widespread impacts on the Bio Marin early clinical pipeline. Key contributions will include informing appropriate preclinical data requirements prior to IND, delivery of initial clinical development plans, pre‑IND and IND documents, and well‑designed clinical trial protocols and supportive documents. In addition, this role will contribute to clinical assessments of new project opportunities (both internal projects and supporting business development activities).

• As a member of preclinical project teams, inform preclinical experimental plans for in vitro and in vivo pharmacology and toxicology packages.
• Develop biomarker strategy for preclinical assets and inform execution of experiments to inform downstream clinical usage in advance of asset entry to the clinic.
• Formulate clinical development plans that serve as the strategic basis for full clinical development of an asset, emphasizing proof of mechanism in first‑in‑human and first‑in‑patient trials and subsequent proof of concept in clinic.
• Serve as clinical development team lead for assets in the research phase through Phase 1 clinical trial completion.
• Lead clinical contributions to pre‑IND and IND submissions (and other stage‑appropriate regulatory submissions).
• Lead clinical contributions to Phase 1 study protocols and trial‑related documents.
• Design and execute natural history studies to deepen understanding of targeted patient populations and develop endpoints for efficient demonstration of POC and/or approval.
• Serve as clinical expert to aid new project identification (both on internal new programs and business development opportunities).
• Represent Experimental Medicine in scientific advisory and academic meetings.
• Serve as Medical Monitor on Bio Marin clinical trials.

• MD required. MD/PhD preferred.
• Ability to work collaboratively in a matrixed, fast‑paced environment.
• Interest and curiosity in development challenges.
• Effective and impactful in a cross‑functional team structure.
• Excellent communication skills, with a desire to develop strong internal and external collaborations.

Note:

This description is not intended to be all‑inclusive, nor a limitation of the duties of the position. It is intended to describe the general nature of the job that may include other duties as assumed or assigned.

Salary range: $228,500 to $310,000. Bio Marin considers a variety of factors when determining base compensation, including experience, qualifications, and geographic location. The position may also be eligible for a discretionary annual bonus, discretionary stock‑based long‑term incentives, paid time off, and a benefits package. Benefits include company‑sponsored medical, dental, vision, and life insurance plans. For additional benefits information, visit