Senior Scientist II, Toxicologist

Who We Are

Bio Marin is a leading rare disease biotechnology company focused on genetically defined conditions.

Guided by our purpose to develop medicines that make a profound impact on people’s lives, our global teams have delivered a portfolio of therapies since our founding in 1997.

Our revolutionary treatments for conditions like achondroplasia (the most common form of dwarfism), PKU (phenylketonuria), CLN2, a form of Batten disease, and a number of forms of MPS (mucopolysaccharidosis) offer new possibilities for patients and families who previously had few, if any, available options.

More recently, with the close of the Amicus acquisition, our portfolio has expanded to include therapies for Fabry disease and Pompe disease, expanding our ability to reach more people living with rare genetic conditions.

Our success comes from our unwavering commitment to excellence, our deep understanding of patient needs, our scientific expertise, and our world-class manufacturing capabilities.

At the heart of Bio Marin is a dedicated team of the brightest minds in the industry working together to deliver innovative therapies to patients and families around the world.

About Worldwide Research and Development

From research and discovery to post‑market clinical development, our R&D engine involves all bench and clinical research and the associated groups that support those endeavors. Our teams work on developing first‑in‑class and best‑in‑class therapeutics that provide meaningful advances to patients who live with rare diseases.

The Pharmacology and Toxicology Department at Bio Marin is seeking a Senior Scientist 2 to provide nonclinical pharmacology and toxicology expertise for the development of Bio Marin’s small molecule and biologic drug candidates.

This individual will provide scientific leadership and play a pivotal role providing nonclinical expertise in support of all phases of the drug development process from late‑stage research through market application and commercialization.

A successful candidate will contribute to the strategic development of Bio Marin’s therapeutics by creating a best‑evidence synthesis of existing knowledge and by designing, implementing, interpreting, investigating and reporting data that elucidates the pharmacologic/toxicologic profile of drug candidates.

This individual will work collaboratively with internal and external cross‑functional subteams, collaborators and consultants to contribute to integrated development pathways including regulatory submissions throughout the drug development cycle.

Comprehensive analysis and interpretations of these studies are reported and defended to regulatory agencies in meetings and documents such as briefing documents, IND/CTA, annual updates, investigator brochures, special protocol assessments and market applications.

The successful candidate will have a pharmacology/toxicology background as well as a strong understanding of Good Laboratory Practices (GLPs) and will provide broad‑based support to align nonclinical efforts with the company’s opportunistic philosophy of drug development.

The candidate will interact with scientists across the company in order to provide a balanced assessment as to the risk/benefit profile associated with a drug candidate’s advancement. The individual will be responsible for the planning, implementation and organization of nonclinical studies along with the use of drug exposure to bridge across species, presentation of data (written and verbal) to cross‑functional core teams and subteams, external collaborators, and the scientific community.

This individual will actively participate in representing Pharmacological Sciences on cross‑functional project teams and/or lead project subteams.

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