Quality Validation Tech

McGuff Pharmaceuticals, Inc. in Santa Ana, CA is looking for a Pharmaceutical Quality/Validation Technician in Santa Ana, CA.

The Quality/Validation Technician (QVT) will work closely with the Quality Engineering and Validation Supervisor to plan, organize and perform commissioning, qualification and validation for defined processes, facilities, equipment and process controls that meet McGuff Pharmaceutical’s high standards. The Technician will maintain the existing manufacturing facilities by primarily maintaining the requalification program.

The QVT will develop, plan, coordinate and execute qualification projects associated with drug product sterile contract manufacturing, aseptic processing, filling, and packaging. The Technician shall be familiar with the qualification of facilities, pharmaceutical manufacturing equipment/systems, sterilization processes, sterile filling processes, cleaning processes, environmental room monitoring, media fills, and process validation runs. The Technician will be capable of executing equipment IQ/OQ/PQ and process validations as required.

In addition, the Technician will also assist, in a team based approach, the development and improvement of processes to ensure such processes meet McGuff Pharmaceutical’s high standards of process capability, reliability, and repeatability.

The Technician will be capable of coordinating and executing process validations and associated system operational needs including, but not limited to, equipment and computer system Installation and Operation Qualifications (IQ/OQ) including temperature mapping, Performance Qualification (PQ) of Utilities, Sterilization and Decontamination Systems, Process Performance Qualification (PPQ), and full process validation documentation. Duties may also include assisting with and evaluating specification development, equipment procurement, operation and maintenance procedure development, and qualifying raw materials, in-process materials and finished goods, as required.

The Technician shall ensure McGuff processes are compliant with cGMP requirements.

• Maintain the validation program for computer systems, facilities, equipment, manufacturing processes in an aseptic filling facility by coordinating, performing and scheduling requalifications and periodic reviews per the validation program.
• Develop and document written qualification/validation protocols and reports.
• Perform and assist with qualification / validation protocols for projects in compliance with McGuff policies and procedures and industry guidelines in the performance of, such as, IQ/OQ/PQ and other validation activities.
• Familiarization of testing procedures as needed for process inputs, outputs and parameters, such as, temperature monitoring, TOC analysis, LAL (Endotoxin), environmental monitoring, bioburden testing, sterility testing, chemical analysis, physical analysis, etc. according to written procedures (SOPs).
• Develop and document written SOPs, as required, for current Good Manufacturing Practices (cGMP).
• Implement document changes and control procedures.
• Conduct QA investigations and follow-up
• Prepare and document procedures and protocols, including commercial batch record preparation and review.
• Participate in Risk Analysis (FMECA’s), as assigned
• Assist with process development for targeted products (under a team approach to product/process development).
• Qualification and review of maintenance procedures and schedules for process equipment troubleshooting and corrective action of processing deviations
• Other related duties as assigned.

• 2 year technical degree required. Bachelor’s degree (B.A./B.S.) of Science in Engineering, Chemistry or related field or equivalent is a plus.
• Prefer minimum of 1-2 years relevant Pharmaceutical/Biotechnology Industry experience with a portion of that experience in manufacturing of sterile injectable drugs via aseptic processing.
• Proficient with computers and related software (Microsoft Office Professional)
• Familiarity with related GMP procedures and requirements. Including knowledge of appropriate Quality Systems and cGMP…