Principal Systems Engineer

The Position

Roche Diagnostics develops and produces medical tests and digital tools that provide information to help health‑care professionals find the right treatment for patients and deliver the best patient care, improving, prolonging, and saving lives.

The Roche Sequencing team is seeking a passionate Systems Integration Engineer/Principal Systems Engineer to join our Systems Integration Group to support the Next Generation Sequencing (NGS) products. This is a hands‑on role; you will be a key contributor in the feasibility, development, and integration phases of end‑to‑end NGS solutions.

Roche Sequencing Solutions is developing new technologies to make genetic testing easy, reliable, and affordable. As a team member on the Systems Integration team, you will learn to use the Roche Single‑Molecule Sequencing platform to optimize the final operating protocols while designing and performing wet‑lab experiments to further develop the sequencing solution through integration of subcomponents and optimization of the entire system.

• You will interpret the experimental results, design experiments, and become an expert on Single‑Molecule Sequencing.
• You will perform a variety of sample prep, library, or sequencing‑related experiments and verification studies.
• You will complete all work using best laboratory practices and maintain a well‑organized and concise record of work performed and progress made.
• You have demonstrated experience for troubleshooting instrument failures with standard root‑cause methods while engaging with SMEs to understand failure modes.
• You understand product requirements in order to develop, execute, and document test cases for verification and validation.

This position is located on‑site in Santa Clara, CA. This is not a hybrid position. Relocation benefits will not be provided.

Required

• You hold a Bachelor’s Degree in chemistry, science, engineering, or other related field with 7 or more years of experience; or a Master’s degree with 5 or more years of experience; or a PhD with 3 or more years of experience.
• You have demonstrated hands‑on experience with PCR, DNA sequencing methods such as raw sample preparation, nucleic acid extraction, library preparation, and NGS sequencing.
• You have a 5 or more years of experience with MATLAB, GIT, Python or similar tools for data analysis and/or automation; experience with statistical tools (e.g., Python/JMP for regression analysis, ANOVA).
• You have 7 or more years of experience in Design of Experiments methodology and application of statistical process control.

Preferred

• You have a proven track record of leading and performing in a fast‑paced, matrix environment; ability to work independently and influence others with strategic decisions.
• You have experience leading and mentoring others; demonstrated collaborative experience.
• You have experience solving unique or unpredictable problems that might have an impact on the goals and objectives as set by the organization.
• You are adept at planning, prioritizing, multi‑tasking, and following through, while remaining highly energetic and focused.
• You have demonstrated interpersonal skills:
  Strong interpersonal, verbal communication and influencing skills; can influence without authority and has proven experience building and cultivating relationships with key partners and stakeholders, both internally and externally.

The expected salary range for this position based on the primary location Santa Clara, CA is $103,600 – $236,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and company performance.

This position also qualifies for the benefits detailed at the link provided below.

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A healthier future drives us to innovate. Together, more than 100,000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products.…