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Principal Mechanical Engineer II; Life Sciences

Job in Santa Clara, Santa Clara County, California, 95050, USA
Listing for: Dawar Consulting
Full Time position
Listed on 2026-07-01
Job specializations:
  • Engineering
    Mechanical Engineer
Salary/Wage Range or Industry Benchmark: 80 USD Hourly USD 80.00 HOUR
Job Description & How to Apply Below
Position: Principal Mechanical Engineer II (Life Sciences)

Principal Mechanical Engineer II

Our client, a world leader in biotechnology and life sciences, is looking for a Principal Mechanical Engineer II based out in Santa Clara, CA. Job Duration:
Long Term Contract (Possibility Of Extension) Pay Rate: $80/hr on W2 Company Benefits:
Medical, Dental, Vision, Paid Sick leave, 401K

Job Summary:

You will lead the design and development of next-generation DNA sequencing instrumentation. This is a hands-on, senior-level role focused on solving complex mechanical challenges at the core of highly integrated life science systems.

Responsibilities:

  • Lead end-to-end mechanical design of complex sub-systems, including electro-mechanical, fluidic, pneumatic, and thermal components
  • Design mechanisms for automated reagent and flow cell handling, sealing, and clamping
  • Architect precision thermal control systems (heating, cooling, sensors, condensation control)
  • Collaborate cross-functionally with electrical, systems, consumables, materials, and assay teams
  • Support system integration, verification, and troubleshooting as the technical owner
  • Drive design reviews, manage technical trade-offs, and deliver design documentation (CAD, drawings, specs)
  • Contribute to future system architecture and technology strategy

Skills /

Qualifications:

  • PhD + 5 years, MS + 10 years, or BS + 10+ years in Mechanical Engineering, Bioengineering, or related field
  • Hands-on experience designing complex life science, diagnostic, or automation instrumentation
  • Strong expertise in fluidics systems (pumps, valves, tubing, sensors)
  • Proven experience in thermal management and precision temperature control
  • Advanced proficiency in 3D CAD (Solid Works preferred)
  • Experience with prototyping, testing, and manufacturing processes (machining, injection molding, 3D printing)
  • Familiarity with Python, LabVIEW, or similar tools for device control and data acquisition
  • Preferred Qualifications:

    Experience with NGS or genomics instrumentation
  • Use of CFD / FEA to guide design decisions
  • Experience in regulated product development environments
  • Demonstrated technical leadership and mentoring experience

If interested, please send us your updated resume at

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