Principal II Automation Research Engineer, Next Gen Sequencing Systems

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The Position At Roche, we are developing the next-generation of sequencing systems. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are also broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing workflows.

Our Workflow Automation R&D Group, a part of Roche Sequencing Solutions, is focused on enhancing sequencing workflows. We are seeking a highly collaborative Principal II Automation Research Engineer to lead and contribute to the research and development of current and future automated platforms, while simultaneously building the tools to democratize key processes and eliminate bottlenecks. This is a hands‑on, multidisciplinary role focused on solving automation challenges, integrating AI tools to streamline workflows, and tackling the fluidic, mechanical and consumables challenges at the heart of our next‑generation platforms.

We are looking for someone who exhibits a high degree of motivation, independence, and resourcefulness to help us develop solutions to our automation challenges in a fast‑paced and collaborative environment.

• You will utilize AI‑assisted coding and modern software development tools to accelerate protocol generation, protocol simulation, debugging, test suite development, and automated error recovery.
• You will use the above tools to fully automate and optimize complex workflows (i.e. sample prep, library prep, target enrichment, quantification, pooling, and sequencing).
• You will test scripts and validate system performance through various analytical equipment and data analysis pipelines.
• You will contribute to architecture, design, research and development of next‑generation automation platforms.
• Design, build, assemble and operate custom test fixtures to support testing of these platforms, modules and sub‑systems.
• You will translate high‑level system and assay requirements into fluidic schematics, system architectures and concepts to evaluate, compare, and down select design paths.
• You will create and maintain comprehensive documentation for all work, from requirements, schematics, diagrams, CAD models, manufacturing drawings, and material specifications.
• You demonstrate strong technical leadership skills and will mentor junior engineers and research staff, fostering a culture of technical excellence and continuous learning within the team.
• You will lead cross‑functional strategy and influence product roadmaps by partnering directly with Assay Development Scientists, Hardware Engineers, Software Developers, and Product Managers.
• Conduct cross‑functional concept, code/script and design reviews.
• Present progress, data, and engineering decisions clearly to stakeholders.

• You have a degree in Bioengineering or Biomedical Engineering, or a closely related discipline, with relevant industry experience (12+ years for a Bachelor's, 10+ years for a Master's, or 7+ year for a PhD).
• You have deep, hands‑on expertise characterizing and testing complex automation systems for sequencing or diagnostics.
• You have demonstrated hands‑on experience using modern AI‑assisted tools to accelerate code generation, parse schemas, and automate test cases.
• You have demonstrated experience with markup and programming languages (e.g., XML, Python) used to define automated instrument steps and hardware execution.
• You have a strong background in experimental design.
• You are highly proficient with machine shop tools, measurement equipment, and rapid prototyping…