Systems Engineer II (PCR​/qPCR​/Sequencing​/troubleshhoting

Our client, a world leader in biotechnology and gene therapy, is looking for a “Systems Engineer II” based in Santa Clara, CA.

Job Duration:
Long Term Contract (Possibility Of Extension) Pay Rate : $57/hr on W2

• Medical
• Dental
• Vision
• Paid Sick leave
• 401K

• Design, execute, analyze, and document experiments supporting NGS feasibility, development, integration, verification, and validation.
• Perform nucleic acid extraction, sample preparation, library preparation, and sequencing experiments.
• Optimize sequencing workflows and operating protocols.
• Troubleshoot instrument, assay, and workflow failures using root cause analysis.
• Develop and execute test cases based on product requirements.
• Apply statistical analysis and Design of Experiments (DoE) methods to interpret data and improve sequencing performance.
• Collaborate with assay, instrumentation, software, bioinformatics, and systems engineering teams.
• Maintain accurate laboratory records and support continuous improvement of sequencing performance, reliability, throughput, and reproducibility.

• Bachelor’s degree with 5+ years of relevant experience, or Master’s degree with 1–3+ years of relevant experience in science, engineering, chemistry, or a related field.
• Hands-on experience with PCR, nucleic acid extraction, DNA sequencing, sample preparation, library preparation, and/or NGS.
• Experience using Python, MATLAB, Git, or similar tools for data analysis or automation.
• Knowledge of statistical analysis, including JMP, regression, and ANOVA.
• Experience with Design of Experiments (DoE) and statistical process control.
• Strong troubleshooting, root cause analysis, data analysis, and technical documentation skills.