RCI-GILD-Research Scientist, Cell Biology – T Cell Biology; MD​/PhD - Santa Monica, CA

Actual

Job Title:

Research Scientist, Cell Biology – T Cell Biology

• Discovery Research is seeking a highly motivated Research Scientist to lead characterization studies that address product efficacy and safety.
• The successful candidate will report to a Director and will be expected to independently design and perform experiments, organize and analyze results, and communicate and present findings in team meetings.

• Execution of cell-based functional and biochemical assays to select candidate molecules for clinical development or support combination strategies to enhance T-cell product potency and safety
• Experimental design aimed to address basic tumor immunology aspects related to the immunosuppressive tumor microenvironment
• Genetic/biochemical manipulation of T-cells and evaluation of impact on T-cell function
• Analyze, organize and communicate results at different research and cross-functional meetings
• Plan and effectively execute experiments based on strategy, project timelines and goals
• Analyze and present scientific results to the project team in addition to cross-functional and cross-site audiences
• Document experimental results to enable subsequent clinical studies and patent applications
• May serve as a core team member or leader on a project team
• Work effectively with other functions (including Process Development, Translational Medicine, Clinical Development) to ensure alignment cross-functionally
• Coordinate tasks across multiple projects, demonstrating prioritization and planning
• May mentor junior team members and supervise the work of a research team including, but not limited to, organizing and prioritizing laboratory work and review of generated experimental results

• Advanced scientific degree (i.e. MD, Pharm
  
  D, PhD)

OR

• Master’s Degree and 6+ years of scientific experience

• Experience designing and developing primary immune cell assays using key immune cell populations
• Hands‑on expertise in T‑cell functional characterization assays including in vitro cytotoxicity, proliferation, cytokine/chemokine measurements, cell signaling, activation, differentiation and exhaustion
• Proficient in cell culture aseptic technique
• Proficient in multi‑parameter flow cytometry (panel design, sample acquisition, data processing) and data analysis (FACSDiva, Flow Jo, Graph Pad Prism, Excel)
• Experience with MSD/ELISA and/or Luminex
• Ph.D. degree in biology‑related field (immunology, cellular and/or tumor biology or a closely related field)
• A strong background in cancer immunotherapy and human immunology, experience working with engineered T cells strongly preferred
• Demonstrated independence in experimental design, data analysis, interpretation, and presentation
• Maintain a high degree of accuracy and attention to detail
• Drive to learn and make a meaningful impact
• Comfortable in a fast‑paced company environment with minimal direction and able to adjust workload based upon changing priorities
• Strong collaboration, excellent interpersonal and communication skills
• Experience using both written and verbal communication, including presentations, to communicate results to a diverse cross‑functional audience
• Strong organizational and record keeping skills
• Self‑motivated, strong sense of responsibility, and willing to accept temporary responsibilities outside of initial job description