Executive Medical Director, Medical Strategy; Hepatologist

Overview

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). Rezdiffra (resmetirom) is a once-daily, oral, liver-directed THR-β agonist for MASH, approved by the FDA and European Commission for treating MASH with moderate to advanced fibrosis (F2 to F3). An ongoing Phase 3 outcomes trial evaluates Rezdiffra for compensated MASH cirrhosis (F4c). Madrigal aims to build a dynamic, inclusive, and high-performing culture that values scientific excellence, operational rigor, and collaboration.

The company is strengthening its workforce strategy to ensure the right talent at the right time, in the right way.

The Executive Medical Director, Medical Strategy (hepatologist) is a key member of the Medical Affairs global team and serves as Madrigal’s clinical and medical expert in MASH. This hepatology/liver expert will bring deep clinical and industry expertise to guide strategic direction and act as a trusted advisor across the organization.

• Strategic and Scientific Leadership:
  Serve as a senior Hepatology clinical and scientific subject-matter expert in MASH and related metabolic liver diseases, providing authoritative medical guidance to internal and external stakeholders. Inform and help shape global medical strategies by contributing deep clinical insight and scientific interpretation within the strategic framework established by Global Medical Strategy leadership. Partner with senior leaders across Global Medical Affairs, R&D, and HEOR to identify critical evidence gaps and drive data generation.
• Act as a senior medical advisor to Commercial and Market Access teams, providing scientific guidance on initiatives requiring medical expertise, in compliance with regulations. Build and maintain relationships with top thought leaders, partnering with MSLs to manage strategic engagements and scientific collaborations.
• Participate in Corporate Advisory Panels to ensure strategic alignment with company-wide initiatives.
• Medical Affairs Research and Evidence Generation:
  Provide senior medical expertise and strategic input for Phase 4 and post-approval studies, in collaboration with Clinical Development leadership; serve as a key medical advisor to HEOR; collaborate to define and execute a real-world evidence agenda; be a core member of the Publication Strategy Review Team (PSRT); support the global Investigator-Initiated Study (IIS) strategy and governance processes with medical review and input.
• Cross-Functional and Operational Integration:
  Serve as a senior Medical Affairs representative on the Medical Product Team (MPT); act as a primary medical partner to cross-functional program teams; provide strategic and scientific review for content to ensure accuracy; review and input on Custom and Standard Response Medical Information documents; advise the Medical Regulatory Committee (MRC); plan and conduct advisory boards; engage as a strategic advisor or member of the Brand Team.
• Field Medical and Scientific Excellence:
  Contribute to training of field medical teams; provide clinical mentorship and ongoing development to enhance scientific acumen and engagement capabilities.
• Organizational Leadership and Talent Development:
  Foster a culture of scientific excellence, collaboration, and continuous improvement within Global Medical Affairs.
• Compliance & Quality:
  Ensure all activities comply with SOPs, industry standards, and applicable regulations; uphold high ethical standards in external engagements.
• Travel Requirement:
  Ability to travel up to 25% for leadership meetings, congresses, corporate locations, and stakeholder engagement.
• Other duties as assigned.

• Hepatologist (MD/DO or equivalent) with clinical experience in MASH.
• 15+ years pharmaceutical (or related) industry experience.
• Deep knowledge of the changing US healthcare environment.
• Excellent interpersonal and communication skills (written and oral).
• Strong scientific/clinical acumen;
• Thorough understanding of US compliance guidelines relevant to the pharmaceutical industry and field medical roles.
• High ethical standards with…