Computational Histopathology Analyst

Computational Histopathology Analyst

GSK is seeking one Senior / Principal Scientist to augment bandwidth within an established computational pathology team of five members at its Upper Providence, PA research site. This is an individual contributor engagement — not a team placement. The contractor will work alongside three colleagues in equivalent roles under the direction of the GSK Technical Lead, integrating directly into day-to-day computational and histotechnology workflows.

The Computational Histopathology Analyst will leverage deep expertise in image analysis, machine learning, and histotechnology to develop, validate, and execute computational pathology algorithms that drive biomarker discovery and translational research  individual will own end-to-end algorithm development using Halo AI (preferred commercial platform), support metadata ingestion workflows into GSK's Image Management System, and contribute hands-on wet lab capabilities to support tissue processing inputs for computational analysis.

All work is conducted under GSK GCP-aligned validation SOPs with documentation maintained in Electronic Lab Notebooks (ELN) and Veeva Vault.

A. Computational Pathology — Algorithm Development & Validation (Primary)

• Develop, optimize, and validate image analysis algorithms and computational pathology pipelines using commercial software — preferred platform:
Halo AI; accepted alternatives include Visiopharm, Cell Profiler, Imaris, and QuPath.

• Execute end-to-end algorithm development lifecycle: method development, internal testing, formal validation, and data delivery per GSK milestone schedule.

• Deliver five complete computational pathology algorithms over the 12-month engagement, each with accompanying validation report and QC-reviewed data output.

• Apply machine learning and quantitative image analysis techniques to analyze histological tissue samples and generate robust biomarker insights.

• Utilize whole-slide imaging platforms and advanced microscopy tools for qualitative and quantitative data interpretation.

• Ensure all algorithmic outputs meet GSK acceptance criteria before submission for sign-off; perform QC review on all executed data prior to delivery.

• Document all development and validation activities in GSK's Electronic Lab Notebook (ELN) and regulatory documentation systems including Veeva Vault, in compliance with GCP standards.

B. Metadata Ingestion & Data Integration

• Design and implement two semi-automated metadata ingestion workflows into GSK's Image Management System to support downstream pathologist and computational analysis pipelines.

• Perform structured metadata mapping across four projects, linking sample metadata to corresponding images in the Image Management System and flagging discrepancies for escalation.

• Manage and organize pathology image metadata to ensure accuracy, consistency, and downstream pipeline readiness.

• Perform data wrangling across multiple file types and formats; apply coding or scripting skills (Python, R, or equivalent) to automate reconciliation tasks where appropriate.

• Maintain rigorous data integrity standards; attention to detail and systematic error-flagging are critical success factors for this role.

C. Wet Lab / Histotechnology Support (Nice-to-Have, Milestones Included)

• Support wet lab histotechnology workflows to produce tissue inputs for computational analysis, including:
Microtomy — sectioning of tissue samples to appropriate thickness for staining and imaging Histological staining — applying and QC-reviewing staining protocols for IHC and special stains Slide scanning and whole-slide imaging using automated platforms Image QC and quality assessment prior to ingestion into computational pipelines

• Operate and oversee automated staining platforms including Ventana Benchmark / Discovery Ultra, Leica Bond RX / Bond III, and Dako Link 48/96; industry-based automated platform experience is strongly preferred over academic manual staining backgrounds.

• Execute five wet lab sample testing assays (Months 7–11), each including full microtomy, staining, imaging, and QC cycle.

• Coordinate tissue processing schedules with…