Director-Head of Molecular Profiling

Director-Head Of Immune Cell Profiling

Vertex Pharmaceuticals is seeking a highly motivated and innovative scientist to join our growing immunology research site in Seattle. This leadership role offers a unique opportunity to shape the future of immunology research by building and leading a cutting-edge Molecular Profiling team. The successful candidate will drive strategy, develop advanced research capabilities, and lead a team of scientists to uncover novel biological insights in order to identify, validate and prioritize therapeutic targets.

In addition, they will develop and execute a strategy for reverse translation optimally enabling serial innovation for immunological indications in line with Vertex's strategic goals.

The Molecular Profiling group will leverage state-of-the-art technologies, including spatial transcriptomics, single-cell RNA/ATAC sequencing, CYTOF, and state of the art proteomics. In close collaboration with the biomarker group the molecular profiling group forms the basis for biomarker discovery. In partnership with the Data & Computational Science group they will be integrating AI/ML-driven data analysis to advance our understanding of human biology and disease.

The Head of Molecular Profiling will also play a pivotal role in fostering external collaborations with academic and industry partners to accelerate innovation and expand capabilities.

• Establish and lead Molecular Profiling capabilities at the Seattle research site, ensuring alignment with Vertex's strategic goals.
• Develop and execute a strategic vision for the Molecular Profiling group, including identifying and prioritizing technology investments in collaboration with partner technology teams.
• Build and lead a high-performing team of scientists, fostering a culture of innovation, collaboration, and scientific excellence.
• Leverage clinical samples to generate novel biological insights and identify high-priority targets and pathways for further investigation in immunology indications.
• Collaborate with the biomarker team to successfully execute on Vertex's biomarker strategy
• Collaborate with Data and Computational Sciences to implement advanced AI/ML approaches for bridging clinical, experimental, and computational teams to nominate novel immunology targets.
• Direct single-cell Multiomics atlases and ML models for data-driven target prioritization across autoimmune disease cohorts.
• Serve as a key member of the Seattle Research leadership team, contributing to the overall strategy and success of the site.
• Act as a leader on interdisciplinary project teams, driving scientific innovation and ensuring alignment with organizational goals.
• Identify and establish external collaborations with academic institutions, biotech companies, and other organizations to enhance Molecular Profiling capabilities as opportunities arise.
• Present findings, strategies, and progress to senior leadership and other stakeholders.

• Ph.D. (or equivalent) in cellular biology, biochemistry, biophysics, or related disciplines with 10+ years of relevant post-doctoral experience
• Proven expertise in spatial transcriptomics, CYTOF, single-cell sequencing, and proteomics.
• Demonstrated experience in complex data analysis, including the application of AI/ML methods to derive novel biological insights.
• Strong leadership skills with a track record of building and managing high-performing teams.
• Excellent communication and presentation skills, with the ability to effectively collaborate across functional groups and present to senior leadership.
• Self-motivated, organized, and adept at solving complex problems in a fast-paced, dynamic environment.
• A passion for innovation and a commitment to transforming the lives of people with serious diseases, their families, and society.

• Experience in immunology research and a deep understanding of immune system biology.
• Experience leading cross-functional teams and managing external partnerships.

Pay Range: $203,000 - $304,400

Disclosure Statement:
The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting…