Senior Scientist Analytical Development Cell Therapy - Seattle WA

Job Description

ATTENTION MILITARY AFFILIATED JOB SEEKERS – Our organization works with partner companies to source qualified talent for their open roles. The following position is available to Veterans, Transitioning Military, National Guard and Reserve Members, Military Spouses, Wounded Warriors, and their Caregivers. If you have the required skill set, education requirements, and experience, please click the submit button and follow the next steps.

Unless specifically stated otherwise, this role is "On‑Site" at the location detailed in the job post.

The Senior Scientist should possess significant hands‑on experience with LC‑MS instrumentation and method development, demonstrate capability in collaborating with other groups such as discovery research, product sciences, and process development. The ideal candidate will be passionate about developing novel medicines, thrive in an intellectually challenging environment, and enjoy collaborating with a team of like‑minded Scientists. This is a lab‑based position, with the level commensurate with experience.

• Act as a subject matter expert to design, develop, optimize, and standardize robust physiochemical methods—including LC, LC‑MS, CE, SEC/AEX‑MALS, preparative LC‑MS—for sample quality control and the characterization of oligonucleotides and proteins.
• Maintain and troubleshoot instrumentation (e.g., UPLC, LC‑MS, CE, MALS, LC‑MS) to ensure high performance, reliability, and minimal downtime in support of critical workflows.
• Maintain meticulous laboratory notebooks and manage routine sample analysis requests.
• Present scientific results and observations to colleagues at cross‑functional meetings, management, and at meetings with external partners.
• Author, review and approve technical documents, including methods, protocols, reports, and regulatory submissions.
• Good knowledge of cGMP and ICH/FDA/EMEA guidance.
• Complete regulatory, site, and department training requirements on a timely basis.

• A PhD with 3+ (or BS with 10+) years of experience in pharmaceutical research, development, or related industry experience.
• Expert in HPLC and LC‑MS instrumentation from multiple vendors (e.g., Vanquish, Waters, Orbi Trap, Q‑Exactive), including setup, operation, troubleshooting, and maintenance, as well as method development.
• Proficient in software such as Empower, Xcalibur, Chromeleon, Biopharma Finder, Protein Metrics, etc.
• Strong background and experience in separations sciences, including but not limited to SEC, RP, IEX, HILIC and CE.
• Expert in developing LC‑MS and LC‑MS/MS methods for large biomolecules (e.g., mAb, ADC, proteins) including intact mass, reduced mass, peptide mapping, and glycan mapping.
• Lead the development of new LC‑MS and LC‑MS/MS analytical methods for the characterization of nucleic acid‑based compounds: oligonucleotides, RNA and DNA‑based modalities.
• Ability to work effectively in a collaborative team setting and in a rapidly changing environment with frequent changes in priorities, which require strong organizational skills.
• Strong written and oral communication skills.
• Experience in CGMP environment is preferred.

If you come across a role that intrigues you but doesn’t perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

Seattle – WA: $128,890 – $156,179