Senior Scientist, Product & Analytical Sciences - Seattle WA

Job Description

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Unless specifically stated otherwise, this role is "On-Site" at the location detailed in the job post.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives. Read more:

The Cell Therapy Product and Analytical Sciences (PAS) team is seeking a Senior Scientist to support the development of the Allogeneic Cell Therapy pipeline programs. The goal of BMS Cell Therapy is to revolutionize medicine by re‑directing the body’s immune cells to specifically target cancer cells. Allogeneic or "off‑the-shelf" CAR T cells are generated from healthy donor‑derived T cells rather than the patient’s T cells and can be delivered to patients without manufacturing wait time.

The Product and Analytical Sciences Team is responsible for developing and executing in depth donor starting materials and drug product characterization strategies, as well as mechanism of action studies to support the development of allogeneic and autologous CAR T cell therapies. The primary focus of the Product and Analytical Senior Scientist role will be to collaborate with PAS team members to build in depth allogeneic CAR T cell donor, product and manufacturing process knowledge, with particular focus on exploratory/investigational studies to drive:

• In depth Healthy Donor cellular starting materials characterization to support donor pre‑screening, selection, cell sourcing workflows across allogeneic cell therapy program
• Developing and executing complex cellular immunoassays and generating comprehensive datasets for correlative analysis execution and the building of in‑depth donor > manufacturing process > drug product understanding across pipeline Allogeneic Cell Therapy Programs
• Support process development studies and investigations by building and mining in depth data packages and generating hypothesis‑driven conclusions and proposed risk mitigation strategies
• Support the identification of drug product critical quality attributes (CQA) to inform the overall drug product control strategy and the generation of drug product quality target product profiles taking into account safety and efficacy of drug products
• Generate in‑depth product characterization data packages for inclusion in regulatory submissions (with specific attention to Module 3 S.3.1. Elucidation of Structure and S.3.2. Product Impurities) and to answer agencies’ information requests

Successful candidates will have a strong foundation in Immunology and human T cell biology and experience with the design, optimization, and implementation of a broad range of in‑vitro cell‑based and/or molecular T cell characterization assays (i.e. cytotoxicity assays, proliferation, cytokine production assays, multi‑color conventional and spectral flow cytometry, gene editing, transcriptome and proteome profiling, etc.). Prior research experience with T cells / CAR T cells (including cell therapy research, allogeneic hematopoietic stem cell transplantation, etc) will be prioritized.

This role is highly collaborative and requires strong ability to prioritize deliverables, independence, a demonstrated ability to support cross‑functional teams, attention to detail, a healthy sense of urgency, and a passion for exploratory and investigational science. Candidates with prior people management experience will be prioritized.

• Work collaboratively with the Product and Analytical Sciences Team members to identify, prioritize and support immediate PAS team goals
• Design, optimize, and execute in-depth characterization…