Principal Research Scientist; LC-MS​/MS

About The Role

As an LC-MS Principal Research Scientist, you will serve as an industry expert for pre‑clinical GLP bioanalytical study method development, validation, and sample analysis utilizing triple quadrupole LC‑MS systems. You will be the expert for ADCs and large molecule LC‑MS/MS analytical assays and sample preparation. Responsibilities include direct interaction with clients, report writing, and adherence to regulatory guidelines. You will collaborate with other scientists, analysts, and departments in a team‑oriented environment.

You must possess knowledge and experience in a Good Laboratory Practice (GLP) environment and be able to adhere to GLP guidelines and practices.

• Provide technical and scientific expertise for small and large molecule analysis via LC‑MS/MS.
• Ensure all work complies fully with GLP requirements, protocols, and SOPs.
• Maintain open and direct communication and attend recurring calls with clients as needed.
• Serve as principal investigator or contributing scientist for LC‑MS/MS studies.
• Prepare all necessary driving documents for in‑lab analysis.
• Complete and deliver scientific reports to clients on time.
• Prepare materials, including animal blood and tissues, for analytical assays to be run on LC‑MS/MS instrumentation.
• Maintain and document chain of custody for specimens, reagents, controls, and samples in the laboratory.
• Perform assays according to protocol with accurate documentation.
• Maintain and update facility records related to the laboratory and its analyses.
• Review laboratory records, procedures, and study data for completeness and accuracy.
• Assist in calibration, optimization, maintenance, and collection of data from analytical instruments.
• Perform routine laboratory maintenance, including cleaning, stocking supplies, and equipment maintenance tasks.
• Document deviations to laboratory procedures and study protocols in a timely manner and provide input for corrective actions.
• Collaborate with internal regulatory departments to ensure quality and compliance oversight on GLP studies.
• Follow Altasciences’ Standard Operating Procedures (SOPs) and comply with GLP, FDA’s ICH M10 guidelines, ALCOA+, USDA, and AAALAC guidelines, identifying areas for improvement.

• Minimum:
  Bachelor’s degree in Immunology, Biology, Chemistry, or another scientific discipline plus a minimum of 5 years of relevant GLP laboratory experience; experience with LC‑MS/MS instrumentation and software; ability to handle multiple projects, prioritize work, and meet deadlines.
• Preferred:
  Master’s degree or PhD in a scientific discipline; ideally a minimum of 5 years as Senior Research Scientist or equivalent in a GLP environment; experience with Shimadzu and SCIEX instrumentation; experience with Watson.

Pay range: $110,000 – $120,000 annually (actual salary may vary based on experience, skills, education, location, and internal equity).

• Health, Dental, Vision insurance plans.
• 401(k) and RRSP with employer match.
• Paid vacation and holidays.
• Paid sick and bereavement leave.
• Employee Assistance and Telehealth programs.
• Telework when applicable.

Altasciences is an equal‑opportunity employer committed to diversity and inclusion. All qualified applicants will receive consideration for employment without regard to age, race, color, religion, creed, sex, sexual orientation, gender identity, national origin, disability, or any other protected class under applicable legislation. Reasonable accommodations for persons with disabilities during the recruitment process are available upon request.