Senior Research Scientist, Target Identification & Validation — Translational Immunology

Key Duties And Responsibilities

• Design, execute, and interpret experiments to identify and validate novel therapeutic targets relevant to autoimmune and inflammatory diseases
• Develop and optimize disease‑relevant in vitro and ex vivo assay systems using primary human immune cells and patient‑derived samples to evaluate target biology and therapeutic potential
• Integrate multi‑dimensional datasets including genomic, transcriptomic, proteomic, and functional data to generate and refine target hypotheses
• Collaborate with data and computational sciences colleagues to leverage large‑scale human datasets for target discovery and prioritization
• Contribute to the design and execution of in vivo studies to assess target relevance and therapeutic mechanisms in preclinical models
• Present scientific findings and strategic recommendations to cross‑functional project teams, senior leadership, and external collaborators with clarity and scientific rigor
• Evaluate and implement emerging technologies and experimental platforms to advance target identification and validation capabilities
• Collaborate closely with immune cell profiling, clinical biomarker, and drug discovery teams to support program progression
  
  Maintain thorough and accurate documentation in electronic laboratory notebooks and contribute to internal knowledge‑sharing
• Stay current with scientific literature to inform research strategy
• Perform other duties as assigned

• Strong expertise in immunology and immune cell biology
• Proven experience isolating, culturing, and functionally characterizing primary human immune cells from peripheral blood and tissues
• Deep proficiency in multi‑parameter flow cytometry (panel design, acquisition, data analysis)
• Hands‑on experience with ELISA, MSD, qPCR, Western blotting, and cell‑based functional assays
• Familiarity with CRISPR‑based gene editing for target validation
• Working knowledge of single‑cell technologies, multi‑omics, and high‑dimensional data analysis
• Basic computational skills (data visualization and statistical analysis)
• Ability to design rigorous experiments and draw clear scientific conclusions
• Excellent written and oral communication skills
• Strong collaboration skills in cross‑functional, multi‑site teams
• Scientific creativity with attention to detail, data quality, and reproducibility

• Ph.D. (or equivalent) in immunology/molecular biology/cell biology/biochemistry or related + 2-5 years post‑doctoral experience, OR
• Master’s (or equivalent) in related field + 5+ years relevant experience, OR
• Bachelor’s (or equivalent) in related field + 8+ years relevant experience

• Annual bonus and annual equity awards
• Medical, dental, and vision benefits; paid time off (incl. week‑long company shutdown in Summer and Winter); educational assistance (incl. student loan repayment); commuting subsidy; matching charitable donations; 401(k)

For accommodation requests related to the hiring process or essential job functions: A