Assistant Investigator - Proteomics at Allen Institute Seattle, WA

Assistant Investigator, Proteomics – Allen Institute for Brain Science

We seek an exceptional individual who will work with a team and will report to the Executive Vice President and Director of the Allen Institute for Brain Science. This individual will lead efforts in the Proteomics Initiative on novel affinity reagents development, and/or characterization of cell‑type specific protein composition and subcellular localization. The proteomic work will provide a critical bridge between the genomic/transcriptomic profiles and the structure/function of brain cell types, leading to both novel insights and foundational resources about the molecular underpinnings of brain circuit function.

The candidate should have an exceptionally strong background in proteomics or protein science, preferably in the context of neuroscience. This person will have an excellent track record of publications and experience in applying for and acquiring funding to support scientific work. The ideal candidate will excel at leading and driving successful projects with internal and external scientific and technological collaborators. And they will fully embrace Allen Institute’s big science, team science, and open science approach.

• Lead the development and implementation of high‑throughput screening and validation of affinity reagents for proteins of interest in the mouse and human brain
• Lead and/or collaborate with other teams to develop multiplexed protein detection approaches
• Lead and/or collaborate with other teams to develop proximity labeling, mass spectrometry, or imaging approaches to profile proteins in specific cell types and subcellular compartments
• Work collaboratively with other Institute teams to build pipelines and scale up proteomic data collection and analysis
• Present a periodic summary of progress to internal and external research community
• Publish and present findings in peer‑reviewed journals and scientific meetings
• Apply for grants as a Principal Investigator

Note:

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

• Ph.D. in Neuroscience, Biochemistry, Molecular Biology, or related field with an emphasis on protein science; or an equivalent combination of degree and experience
• Minimum of 5 years of relevant post‑doctoral experience
• Strong background in proteomics methods
• Strong proven publication record
• Broad knowledge in molecular biology, cell biology, and neuroscience

• Experience in antibody or other affinity reagent development, proximity labeling, mass spectrometry, expansion microscopy, or multiplexed protein detection
• Hands‑on experience in wet lab execution of proteomic experiments
• Experience in relevant computational data analysis methods
• Experience in acquiring grants or other external funding
• Exceptional oral and written communication and organizational skills
• Ability to work independently and within a collaborative, multi‑disciplinary environment to meet aggressive timelines
• Ability to guide teams and coordinate activities within and across institutions, including coaching/mentoring junior members

• Exposure to and handling of laboratory animals required
• Laboratory environment — possible chemical, biological, or other hazardous substances exposure.
• Possible exposure to Bio Safety Level 2 organisms, such as recombinant viruses
• This may include wearing personnel protective equipment (PPE)
• Working with dry ice or liquid nitrogen
• Sample handling of the following material, including but not limited to: human whole blood, PBMC, plasma, nucleic acids, and cells

• Fine motor movements in fingers/hands to operate computers and other office equipment; repetitive motion with lab equipment

• This role is currently working onsite and is expected to work onsite for the majority of working hours. The primary work location for this role is 615 Westlake Ave N., with the flexibility to…