Senior Principal Scientist, Drug Product Analytical Science and Technology; ASAT), Cell Therapy

Position Summary

This technical leadership role is a highly experienced subject matter expert in molecular biology analytical methods and related areas, responsible for leading the design, execution, and interpretation of complex, high impact scientific programs. The role will manage a team responsible for method optimization, transfer, and validation in support of the Cell Therapy analytical portfolio. The Senior Principal Scientist balances deep hands‑on laboratory engagement with cross‑functional leadership, mentoring, and delivering enterprise‑level impact.

• Lead and manage a team responsible for molecular biology method technical investigation, optimization/remediations, transfer and validation in compliance with regulatory requirements.
• Perform or direct hands‑on laboratory work to support commercial QC analytical methods, connecting lab‐level science to portfolio strategy, pipeline value, and organizational mission.
• Critically evaluate experimental data across the team, identifying scientific risks and opportunities, and recommending course corrections.
• Act as a subject matter expert in functional areas as needed.
• Make high‑impact scientific and strategic decisions under uncertainty, balancing scientific ambition with pragmatic risk management.
• Represent the department in product review boards and regulatory inspections, authoring relevant analytical sections of regulatory submissions.
• Implement method lifecycle and maintenance programs for viral vector and cell therapy drug products.
• Partner with development organizations in designing qualification studies and optimizing methods.
• Represent ASAT interests on cross‑functional and cross‑site teams, communicating and collaborating effectively.
• Apply technical knowledge and regulatory requirements to troubleshoot complex non‑routine issues.
• Hire, mentor, and develop exceptional ASAT personnel.

This position will report to Analytical Science and Technology management.

Strong scientific background and expertise with various molecular methodologies, including lentiviral, AAV vectors, and gene delivery platforms. Demonstrated advanced technical writing skills, high‑level strategic thinking, problem‑solving ability, and the capacity to work independently in a fast‑paced matrix environment. Track record of scientific productivity with publications or internal contributions. Advanced communication skills for collaboration with peers, senior management, and cross‑functional teams. Ability to write formal reports and technical presentations.

Experience in leading teams and mentoring staff. Willingness to travel as needed.

• Bachelor’s or Master’s degree in bioanalytical science or related field; advanced degree preferred.
• 10+ years of relevant experience in regulated cellular therapy or gene therapy, or an equivalent combination of education and experience.
• Expert knowledge of molecular techniques such as lentiviral, AAV vectors, ELISA, flow cytometry, and bioanalytical method lifecycle.
• Experience in cGMP regulations and application within a Quality Control environment. Knowledge of FDA, EMA, ICH, USP, and EP guidelines.

Seattle, WA: $152,820 – $185,184 (full‑time employee). Additional incentive cash and stock opportunities may be available based on eligibility. Final compensation will be determined by demonstrated experience.

• Health coverage: medical, pharmacy, dental, and vision care.
• Well‑being support: BMS Well‑Being Account, BMS Living Life Better, and Employee Assistance Programs.
• Financial wellbeing: 401(k) plan, short‑ and long‑term disability, life insurance, accident insurance, supplemental health insurance, travel protection, personal liability protection, identity theft benefit, legal support, and survivor support.

• US exempt employees: flexible time off (unlimited with manager approval), 11 paid national holidays, and optional unpaid holidays.
• Phoenix, AZ, Puerto Rico, and Rayzebio exempt employees: 160 hours annual paid vacation, 11 national holidays, and optional holidays.

Support for People with Disabilities: BMS is dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations, and ongoing support. For more information, visit

BMS will consider for employment qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

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