Immunology Senior Research Scientist - Single-Cell Genomics

Vertex is a global biotechnology company focused on developing transformative medicines for patients with serious diseases. We are looking for a Senior Scientist, Single‑Cell Genomics to lead the design, execution, optimization, and interpretation of single‑cell genomics and multi‑omics workflows.

• Execute single‑cell genomics and multi‑omics workflows.
• Process primary samples and cell‑based systems for single‑cell applications, including tissue dissociation, cell isolation, enrichment, counting, and viability assessment.
• Generate high‑quality libraries for transcriptomic, epigenomic, and/or immune profiling applications.
• Perform sample and library QC using standard methods such as Qubit, Tape Station, and Bioanalyzer.
• Perform end‑to‑end single‑cell genomics and multi‑omics workflows, including emerging modalities such as multiome and CITE‑seq where appropriate, from sample acquisition through library preparation and sequencing.
• Establish and refine SOPs, assay documentation, and experimental best practices.
• Execute and troubleshoot assays using 10x Chromium and related technologies; troubleshoot technical issues across the workflow, including sample quality, library complexity, and sequencing performance.
• Optimize workflows as needed to maximize sample quality, cell recovery, and reproducibility across studies.
• Benchmark new methods and contribute to adoption of next‑generation single‑cell and multi‑omics capabilities.
• Coordinate with internal core groups or external vendors for sequencing, run tracking, and data generation; support or interface with flow cytometry and cell sorting activities where needed to enable downstream genomics workflows.
• Collaborate closely with bioinformatics and computational biology teams to support interpretation of complex datasets and enable biologically meaningful insights.
• Perform critical evaluation of assay and sequencing metrics, including read depth, mapping performance, cell recovery, and QC thresholds.

• Deep hands‑on expertise in single‑cell genomics workflows, with particular experience in 10x Genomics platforms.
• Strong wet‑lab background in NGS library preparation, molecular biology, and complex sample processing.
• Demonstrated ability to independently design, execute, troubleshoot, and optimize technically sophisticated experiments.
• Experience with downstream computational analysis of single‑cell datasets is not required but would be considered a significant advantage.
• Strong attention to detail and commitment to high standards in experimental rigor, data quality, and documentation.
• Effective communicator and collaborative scientist who works well in multidisciplinary, matrixed research environments.

PhD in Genomics, Molecular Biology, Chemical Engineering, Bioengineering, or a related discipline with 2+ years of relevant experience; or Master’s degree with 6+ years of relevant experience; or Bachelor’s degree with 8+ years of relevant experience.

$124,200 – $186,400. This role is eligible for an annual bonus and annual equity awards. Additional benefits include medical, dental, vision, paid time off, educational assistance, commuting subsidy, charitable donation matching, 401(k), and more.

On‑site. Five days per week on‑site with ad‑hoc flexibility. Flex status is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.