Scientist I - Amyotrophic Lateral Sclerosis

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Scientist I
- Brain Health
- Amyotrophic Lateral Sclerosis

The Allen Institute accelerates science for a healthier world through large-scale research designed to answer some of the most complex questions in biology. Our multi-disciplinary teams generate foundational knowledge, tools, and data to understand how our brain, cells, and immune system work. We share our work openly so others can build on it, move faster, and ask bigger questions. We drive discovery forward and create new possibilities for improving human health.

The goal of the Brain Health accelerator is to revolutionize the treatment of brain diseases by creating the first dual-use molecular tools that can not only reveal information about the diversity of cells in the human brain but also be used to target novel treatments to specific types of cells.

We are seeking a highly motivated Scientist to establish and optimize single cell long-read sequencing methods (e.g., Pac Bio HiFi/Kinnex or Oxford Nanopore), validate molecular and single cell assays, and execute experiments (e.g., in situ hybridization, immunostaining) to validate computational findings. Working closely with experts in neuropathology, spatial transcriptomics, and computational analysis, the Scientist will help advance high-resolution molecular atlases of the human nervous system in health and disease.

The ideal candidate will have a strong foundation in molecular neuroscience, experience with single cell transcriptomic and/or epigenomic assays, and a working knowledge of ALS biology. Familiarity with long-read sequencing platforms and enthusiasm to establish novel molecular assays are also essential.

At the Allen Institute, we believe that science is for everyone - and should be open to everyone. We are dedicated to combating biases and reducing barriers to STEM careers more broadly.

We also believe that science is better when it includes different perspectives and voices. We strive to make the Allen Institute a place where everyone feels like they belong and are empowered to do their best work in a supportive environment.

We are an equal-opportunity employer and strongly encourage people from all backgrounds to apply for our open positions.

• Contribute to the design and execution of large-scale single cell genomics experiments
• Lead the development and testing of new long-read sequencing methods and protocols
• Optimize protocols for challenging samples, troubleshoot workflows for variable tissue quality, and evaluate tissue and sequencing library quality using standard metrics
• Conduct basic analysis of single cell and long-read genomics data, including benchmarking of new methods
• Present progress in group meetings and at scientific conferences, and contribute to peer-reviewed publications
• Assist in management of tissue acquisition and sample tracking
• Maintain meticulous experimental records to ensure reproducibility across tissue donors and adherence to best practices for tissue handling, biosafety, and data integrity
• Actively contribute to a collaborative environment focused on scientific rigor and methodological innovation

* Note:

Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.*

• PhD degree in Neuroscience, Molecular Biology, Genomics, or related field, or equivalent combination of degree and experience
• Demonstrated experience conducting independent experimental research and interpreting complex biological data
• Broad knowledge of and experience with single cell genomics platforms

• Proficiency in independently conducting single cell genomics assays
• Experience establishing or optimizing long-read sequencing workflows (e.g., Pac Bio HiFi/Kinnex or Oxford Nanopore)
• Hands‑on experience with human brain and/or spinal…