Scientist​/Senior Scientist, Protein Engineering

Dovetail Therapeutics is a Seattle biopharmaceutical company founded in 2023 by the world’s leading healthcare venture capital firm Orbi Med. Dovetail is committed to developing novel biotherapeutics that will meaningfully improve the lives of patients. The company has established a transformative, proprietary platform and a robust, expanding pipeline, with its lead drug candidate entering the clinic this year.

Dovetail Therapeutics is seeking a talented and motivated Scientist/Senior Scientist, Protein Engineering to join our growing and dynamic team. If you are passionate about developing the next generation of biotherapeutics in a collaborative and fast-paced environment where your contributions will make a real difference, this role is for you.

• Lead and contribute to discovery and optimization efforts for antibody candidates
• Collaborate closely with cross-functional internal teams and external CRO partners to design and advance novel biotherapeutic programs
• Develop and implement innovative strategies and enabling methodologies to accelerate antibody discovery and engineering workflows
• Analyze and effectively communicate ideas and findings to internal stakeholders

• Expertise in antibody and protein science, molecular biology, and biotherapeutic discovery
• Hands‑on experience in therapeutic protein and antibody engineering, particularly with optimization of molecular properties, affinity maturation, and/or antibody humanization
• Proven ability in applying state‑of‑the‑art antibody engineering approaches, sequence analysis, and computational tools to shape design strategy and optimize workflows
• Experience using AI/ML‑driven structural modeling to guide antibody design
• Strong ability to integrate functional and biophysical data, including high‑throughput datasets, to drive candidate selection and engineering decision
• Stay current on emerging trends in protein design and introduce innovative techniques to expand team capabilities

• Ph.D. degree in structural biology, molecular biology, biochemistry or a related field
• 3+ years of experience in antibody discovery and protein engineering in an academic or industry setting; 2+ years of industry experience strongly preferred
• Excellent organizational and communication skills with attention to detail
• Ability to work in a fast‑paced, interdisciplinary environment

We foster a culture of collaboration and innovation, with each team member playing a critical role in shaping our success. Dovetail offers a competitive total compensation and benefits package. Benefits include medical, dental and vision coverage, paid parking or transit, a 401(k) plan, and paid time off, among other components.

Dovetail Therapeutics is located at 1616 Eastlake Avenue East, in the vibrant South Lake Union neighborhood of Seattle.