Researcher III

Cognizance Technologies, LLC | Full time

Silver Spring, United States | Posted on 05/29/2026

The candidate will assist OPQ/OPQR scientists with the development and testing of novel technologies for the identification and characterization of glycans on therapeutic glycoproteins. In addition to participating in research and development activities, the candidate will collect and analyze data and be responsible for completing internal technical reports detailing procedures, outcomes, and observations, and drafting manuscripts for publications. The selected professional must be able to work towards and accomplish the tasks outlined below.

Perform analytical laboratory testing for therapeutic proteins, such as monoclonal antibodies, fusion proteins, enzyme-replacement therapies, and other protein products from multiple sources and compile sample information into multiple databases/data management systems;

• Operate and maintain advanced analytical instrumentation such as liquid chromatography (U/HPLC) systems, capillary electrophoresis systems, and mass spectrometers for the analysis of protein products and for development of novel technologies for profiling glycans on glycoproteins.
• Culture mammalian (CHO) and/or bacterial cells using aseptic techniques for suspension cell culture and analysis with shake flasks, spin flasks, and other cell culture techniques;
• Purify the therapeutic proteins produced by engineered CHO cell lines;
• Analyze glycoproteins, including glycoprotein drugs, endogenous glycoproteins and otherglycoconjugates with mass spectrometry (MS), such as MALDI-TOF, LC-MS, and Ion-mobilityspectrometry–MS (IMS-MS or IMS), (U)
  HPLC and other state-of-the-art technologies;
• Establish new analytical methods to release and analyze O-glycans from glycoproteins;
• Establish new analytical methods to identify the O-glycosylation sites of glycoproteins including protein drugs;
• Collect sample information and laboratory testing results from multiple sources and databases;
• Perform data processing and analysis of acquired data;
• Assist with laboratory equipment maintenance and repair;
• Assist with the upkeep of inventory of lab supplies and laboratory equipment and instrumentation;
• Prepare Word summary report or Power Point presentation on work projects and progress when requested by program lead;
• Have weekly meetings with program lead for update briefing or issues;
• Provide status reports to the program lead according to the schedule provided above;
• Write manuscripts and/or technique reports for publications or white papers on the project;
• Complete all mandatory FDA training and maintain required credentials

Master’s or Ph.D. degree in Chemistry,Glycobiology, Glycochemistry, Biochemistry, Cell Biology, Biotechnology, Bioengineering, or related course(s) of study and a minimum of four (4) years’ post-graduate experience. Preference will be given to candidates with prior experience in developing advanced analytical techniques for the comprehensive characterization of therapeutic proteins, including monoclonal antibodies, fusion proteins, and antibody drug conjugates. A working knowledge of biopharmaceutical manufacturing, process development, and biotechnology research are also preferred, although experience in developing quality analytics in arelevant field will be considered