Postdoctoral Fellow ; Antibody Engineering

About the Position

We are seeking a highly motivated and skilled Postdoctoral Fellow/Consultant to support the Principal Investigator, Co-Investigators, and research staff in the development and evaluation of next-generation prophylactics. The successful candidate will conduct proof-of-concept studies involving the design, expression, purification, and characterization of antibodies, single-chain variable fragments (scFvs), and bispecific scFvs (BS-scFvs) targeting key vaccine candidates. This position offers an exceptional opportunity to work at the intersection of computational protein design, structural biology, artificial intelligence, and translational vaccinology within a highly collaborative research environment.

The candidate will bridge computational approaches with hands-on wet-laboratory research and contribute to the advancement of novel prophylactic strategies. In addition to laboratory and research responsibilities, the Postdoctoral Fellow/Consultant will assist with overall project execution, including ensuring enrollment targets are met when applicable, maintaining protocol adherence, supporting monitoring visits, overseeing regulatory and administrative requirements, assisting with data management, and providing project close-out support.

The successful candidate will work closely with investigators and research staff to ensure scientific, operational, and regulatory objectives are achieved.

Work Authorization Requirement:
Must be a U.S. citizen or permanent resident, or otherwise authorized to work in the United States without employer sponsorship.

• 1. Computational Antibody & Protein Design:
  Use machine-learning/AI platforms including Alpha
  
  Fold3, RF diffusion, ThermoMPNN, Rosetta, PROSS, PRoscan, PyMOL.
• 2. Recombinant Protein Expression & Purification:
  Express proteins in mammalian expression system, Escherichia coli or alternative expression hosts. Perform protein purification using chromatography platforms (FPLC, affinity, size-exclusion chromatography).
• 3. Biophysical & Biochemical Characterization:
  Evaluate the purity, yield, and structural integrity of protein molecules, conduct ELISA, Biolayer Interferometry to benchmark candidate molecules.
• 4. Project Management, Collaboration & Reporting:
  Analyze, interpret, and integrate biochemical/biophysical datasets with downstream biological assay results generated by partners. Draft technical updates and final comprehensive reports for the project sponsor.

Education:

Ph.D. in Biochemistry, Biophysics, Molecular Biology, Bioengineering, or a closely related scientific discipline.

Wet-Lab

Experience:

Expertise in recombinant protein expression mammalian and bacterial systems. Extensive experience in protein purification (IMAC, SEC, IEX) and quality control (SDS-PAGE, Western blot, HPLC). Demonstrated familiarity with structural and biophysical characterization techniques, particularly BLI/SPR.

Skills:

Excellent communication, meticulous record-keeping, and the ability to work independently within a multidisciplinary, collaborative team environment.

Preferred Qualifications Computational

Skills:

Direct experience using computational protein engineering suites.

As a leader in military medical research, at Geneva, our professionals develop critical solutions – and build rewarding careers.

Our team of more than 400 employees across the world joins forces with some of the world’s leading researchers and innovators, who are committed to the advancement of military medicine worldwide.

Transforming Military Medicine to Save Lives Worldwide Geneva is a 501(c)3 nonprofit that advances military medicine through research, development, and education as we pursue our purpose to ensure optimal health for service members and the communities they serve.

The Geneva Foundation is an equal opportunity employer.

• Our benefits package includes financial rewards that are a significant part of the employee's total rewards compensation package.
• Geneva's highly competitive benefits include medical, dental, and vision healthcare, Flexible Spending Account, Health Savings account, with employer contribution.
• Coverage is provided for employees and family members including domestic partners.
• Short-and long-term disability, Employee Assistance Program, Life & ADD insurance, 403b retirement plan with generous employer match, flexible leave options, 11 paid holidays per year, and up to 4 weeks of paid time off in a rolling year.
• Employees may qualify for PSLF as Geneva is a 501(c)(3) nonprofit organization.
• Full time positions come with all benefits.
• Part time and intermittent positions may vary.