Scientist , Genotox

Qualifications

• PhD with 0-2 years of experience in academic or industry setting, MS with 6+ years of experience, or BS with 8+ years of experience
• Broad knowledge of genome editing technologies and associated off‑target discovery assays
• Genomic assay development or deployment experience for off‑target discovery, verification, and structural variation assessment
• Familiarity with NGS workflows and library preparation
• Experience deploying PCR‑based off‑target verification assays such as rhAmpSeq and Hybrid Capture Sequencing
• Experience developing and deploying unidirectional/ligation‑mediated PCR assays
• Proficiency in assay‑related molecular biology techniques including DNA extraction, nucleic acid quality assessment, and primer design
• Basic cell biology skills including cell line culture and manipulation techniques (electroporation and transfection)
• Strong written and verbal communication skills

• Developing and deploying assays for genomic safety assessment for Gene Writer candidates
• Developing, deploying, and analyzing NGS‑based assays for off‑target discovery and verification
• Examining genome structural variants using optical and molecular methods
• Working collaboratively with genomic safety, molecular assay, computational biology and regulatory science teams to advance therapeutic programs
• Contributing to scientific report writing, translating complex experimental findings to support regulatory and research goals

About you:

You are a rigorous, detail‑oriented scientist with expertise in genome editing and genomic safety assessment. As a Scientist I on our Genomic Safety team, you will design, develop, and deploy cutting‑edge assays to characterize the off‑target landscape of our Gene Writer therapeutics at the intersection of molecular biology, next‑generation sequencing, and translational safety science. You bring hands‑on experience with NGS workflows, off‑target discovery platforms, and PCR‑based verification methods, and you thrive in a fast‑moving environment where scientific rigor and program momentum go hand in hand.

You are equally comfortable at the bench and in cross‑functional discussions, communicating your findings clearly to genomic safety, computational biology, and regulatory colleagues.

Compensation:
Pay Range: $52.00 - $58.00 USD per hour

Tessera Therapeutics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic identified by federal, state, or local laws where we operate. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities.