Scientist I​/II, Bioanalytical; LC-MS

Somerville, Massachusetts, United States

• PhD in Analytical Chemistry or related discipline (e.g., Biochemistry, Biotechnology or Pharmaceutical Science), with 0-3 years of industry experience in biotech, pharmaceutical, and/or CROs. Postdoc experience is a plus.
• Hands‑on experience in LC‑MS based bioanalysis of proteins, oligos or small molecules in biological matrix is required.
• In‑depth scientific knowledge and hands‑on technical expertise on LC‑MS, LC‑MS/MS, and chromatography methodologies and instrumentation is required.
• Proficiency with Sciex Triple Quadrupole LC‑MS/MS system or Thermo Orbitrap mass spectrometers such as Q Exactive or Exploris series.
• Experience with lab automation technologies is a plus.

• Develop, optimize, and validate bioanalytical methods to measure proteins, oligos, and lipids in biological samples, including cells, biofluids, and tissues, to support discovery, preclinical, and clinical programs.
• Design and execute experiments from sample preparation, LC‑MS/MS operation to data analysis and interpretation.
• Guide CROs for method transfer and serve as technical expert for method troubleshooting.
• Write internal assay protocols, ROPs, qualification plans, and sample analysis reports.
• Provide maintenance, quality control and troubleshooting of LC‑MS systems.

We are seeking a highly motivated bioanalytical scientist to fulfill a Scientist role in our DMPK group. The candidate will be responsible for developing and employing LC‑MS methods to characterize and quantify proteins, oligos and lipids in cells, blood and tissues to support discovery, preclinical, and clinical programs for a variety of therapeutic indications. The ideal candidate must have excellent communication skills and is willing to work in a highly dynamic and fast‑paced environment.

Per year salary range: $109,000 - $143,000. The role is eligible for an annual incentive bonus and equity grants as part of Tessera’s total rewards program.

Tessera offers a comprehensive benefits program including group medical, vision, and dental coverage; group life and disability insurance; a 401(k) plan with company contribution; tuition reimbursement; and more.

Tessera is proud to be an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression or any other characteristic identified by federal, state, or local laws where we operate. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities.