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Scientist I​/II, Bioanalytical; LC-MS

Job in Somerville, Middlesex County, Massachusetts, 02145, USA
Listing for: Tesseratherapeutics
Full Time position
Listed on 2026-07-07
Job specializations:
  • Research/Development
    Research Scientist, Biotech Research, Pharmaceutical Science/ Research
Salary/Wage Range or Industry Benchmark: 109000 - 143000 USD Yearly USD 109000.00 143000.00 YEAR
Job Description & How to Apply Below
Position: Scientist I/II, Bioanalytical (LC-MS)

Requirements

  • PhD in Analytical Chemistry or related discipline such as Biochemistry, Biotechnology, or Pharmaceutical Science, with 0‑3 years of industry experience in biotech, pharmaceutical, and/or CROs. Postdoc experience is a plus.
  • Hands‑on experience in LC‑MS based bioanalysis of proteins, oligos, and small molecules in biological matrices is required.
  • In‑depth scientific knowledge and hands‑on technical expertise in LC‑MS, LC‑MS/MS, and chromatography methodologies and instrumentation is required.
  • Proficiency in using Sciex Triple Quadrupole LC‑MS/MS systems or Thermo Orbitrap mass spectrometers such as the Q Exactive or Exploris series.
  • Experience with lab automation technologies is a plus.
Responsibilities
  • Develop, optimize, and validate bioanalytical methods to measure proteins, oligos, and lipids in biological samples—including cells, biofluids, and tissues—to support discovery, preclinical, and clinical programs.
  • Design and execute experiments from sample preparation, LC‑MS/MS operation to data analysis and interpretation.
  • Guide CROs for method transfer and serve as technical expert for method troubleshooting.
  • Write internal assay protocols, ROPs, qualification plans, and sample analysis reports.
  • Provide maintenance, quality control, and troubleshooting of LC‑MS systems.
About the Candidate

We are seeking a highly motivated bioanalytical scientist to fulfil a Scientist role in our DMPK group. The candidate will be responsible for developing and employing LC‑MS methods to characterize and quantify proteins, oligos, and lipids in cells, blood, and tissues to support discovery, preclinical, and clinical programs for a variety of therapeutic indications. Excellent communication skills and adaptability to a highly dynamic and fast‑paced environment are essential.

Compensation

Base salary range: $109,000 – $143,000 per year. The position may also be eligible for annual incentive bonuses and equity grants.

Benefits

We offer a comprehensive benefits program that includes group medical, vision, and dental coverage; group life and disability insurance; a 401(k) plan with company contribution; tuition reimbursement; and more.

Equal Opportunity Employer

We are an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship status, sexual orientation, gender identity or expression, or any other characteristic protected by applicable laws. We provide reasonable accommodations to qualified applicants and employees with disabilities.

Application Process

All inquiries regarding the posted position should be directed to our Talent Partner. Interested individuals must apply directly to be considered for the opening.

Recruitment & Staffing Agencies

We do not accept unsolicited resumes from any source other than candidates. Resumes submitted by recruitment or staffing agencies without a signed agreement will automatically become the property of our company, and we will not owe any referral or other fees.

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