Senior Director, In Vivo Pharmacology

The Role:

Gnerate:

Biomedicines is a new kind of therapeutics company at the intersection of machine learning, biological engineering, and medicine, pioneering Generative Biology to create breakthrough medicines where novel therapeutics are computationally generated rather than discovered.

We are seeking a Senior Director, In Vivo Pharmacology to provide scientific and organizational leadership for in vivo pharmacology and help advance a growing portfolio of novel biologic medicines from early discovery through development.

Reporting to the Head of Preclinical Pharmacology, this individual will lead and develop a team of in vivo pharmacology scientists while shaping and executing in vivo pharmacology strategies across programs. In close partnership with Preclinical Pharmacology, Early Biology, and other scientific and development functions, the Senior Director will ensure that in vivo studies are tightly connected to mechanistic understanding, in vitro functional and high-throughput data, and emerging translational evidence.

The Senior Director will also work closely with the translational biology function to help establish and incorporate appropriate human experimental systems and New Approach Methodologies (NAMs) into preclinical pharmacology strategies where they can add value. This will complement and inform traditional in vitro and in vivo approaches and help strengthen the connection between preclinical findings and human biology for more informative and successful FIH studies.

This role sits at the intersection of scientific strategy, experimental execution, and organizational leadership. The Senior Director will connect technology and mechanism to pharmacology, pharmacology to translation, and experimental evidence to program decisions. They will work across functions to ensure that pharmacology strategies are rigorous, appropriately quantitative, and aligned with development objectives and regulatory expectations.

The successful candidate will bring deep expertise in in vivo pharmacology and drug development, strong scientific judgment, and a demonstrated track record of building and developing high-performing scientific teams. Equally important, they will thrive in an environment that values scientific rigor, innovation, thoughtful experimentation, collaboration, transparency, and the willingness to challenge conventional approaches in pursuit of better medicines for patients.

Here's how you will contribute:

Scientific and Strategic Leadership
· Provide strategic and scientific leadership for in vivo pharmacology across discovery and development programs, translating program hypotheses into rigorous, decision-enabling experimental strategies.
· Partner with program and functional leaders to develop integrated pharmacology plans encompassing model selection, study design, pharmacodynamic and efficacy endpoints, dose and schedule optimization, and translational strategies.
· Critically evaluate the relevance, strengths, and limitations of in vivo models and develop fit-for-purpose approaches that reflect disease biology, mechanism of action, therapeutic modality, and stage of development.
· Integrate in vivo pharmacology and PK/PD findings with in vitro functional and high-throughput data, translational biology, biomarkers, safety, and other relevant datasets to build a cohesive understanding of therapeutic activity and inform candidate progression.
· Apply strong scientific judgment to complex and ambiguous datasets, identifying key risks, knowledge gaps, and opportunities for experiments or technologies that can efficiently resolve uncertainty.
· Serve as a senior pharmacology partner on cross-functional program teams, influencing program strategy and communicating scientific…