Scientist , Oligonucleotide Chemistry

Somerville, Massachusetts, United States

• BS/MS/PhD in Chemistry, Biochemistry, Chemical Engineering, or related field with 8+ years (BS) or 6+ years (MS) or 0-2 years (PhD) of relevant industry experience
• Excellent knowledge of upstream and downstream processing of oligonucleotides
• Experience with Äkta
  100 oligonucleotide synthesizer
• Experience with Mermade
  192 and Mermade
  12 synthesizers is a plus
• Experience with HPLC purification and analytics of guide RNA preferred
• Experience with enzymatic ligation techniques is a plus
• Experience using ELNs to document experimental results is a plus

• Developing processes and implementing strategies for internal production of guide RNA to support platform research and pre‑clinical activities
• Optimizing synthetic reactions and purification methods of drug candidates to ensure scalable and cost‑effective processes for oligonucleotide manufacturing
• Working in collaboration with the Internal Manufacturing team during process transfer
• Participate in cross‑functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing
• Supporting the CMC teams management of external vendors

You are a skilled, tenacious, and self‑motivated individual capable of developing robust processes for synthesizing and purifying complex oligonucleotides. You can operate in a fast‑paced environment, troubleshoot instruments, reduce workflow inefficiencies, and document operations independently as well as part of a team. You are experienced with, and can independently operate, a Cytiva Äkta
100 to synthesize oligonucleotides. You are familiar with standard cleavage and deprotection procedures as well as TFF operation. You are equipped with strong communication skills, which will be pertinent for presenting data internally and cross‑functionally. You enjoy overcoming challenges in collaboration with colleagues.

Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.

The stated base salary range represents Tessera’s good‑faith estimate for this role. Actual compensation will be determined based on a number of factors, including but not limited to individual qualifications, years of relevant experience, internal compensation alignment, and external market data.

Tessera offers a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness, and financial security of our employees and their families. Benefits currently include group medical, vision, and dental coverage; group life and disability insurance; a 401(k) plan with company contribution; tuition reimbursement; and more.

This position is also eligible for an annual incentive bonus and equity grants as part of Tessera’s total rewards program.

Per Year Salary Range: $109,000 - $124,000 USD

Tessera Therapeutics is pioneering Gene Writing™— a new biotechnology designed to give scientists and clinicians the ability to write small and large therapeutic messages into the genome, thereby curing diseases at their source. Gene Writing holds the potential to become a new category in genetic medicine, building upon recent breakthroughs in gene therapy and gene editing while eliminating important limitations in their reach, utilization, and efficacy.

Tessera is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, age, sex, national origin, disability status, marital status, genetics, protected veteran status, citizenship, sexual orientation, gender identity, or any other characteristic identified by default. Tessera provides reasonable accommodations to qualified applicants and employees with disabilities. For interactive dialogue regarding reasonable accommodations in connection with the hiring process, please contact