Senior Research Associate, Oligonucleotide Chemistry

Your experience includes…

• BS/MS in Chemistry, Biochemistry, Chemical Engineering, or related field with 5+ years (BS) or 3+ years (MS) of relevant industry experience
• Experience with upstream and downstream processing of oligonucleotides
• Must have experience with Mermade
  192 and Mermade
  12 synthesizers
• Experience with Äkta
  100 oligonucleotide synthesizer is a plus
• Experience with HPLC purification and analytics of guide RNA preferred
• Experience with enzymatic ligation techniques is a plus
• Experience using ELNs to document experimental results is a plus

• Performing small scale, high throughput internal production of guide RNA to support platform research and pre-clinical activities
• Optimizing synthetic reactions and purification methods of drug candidates to ensure scalable and cost-effective processes for oligonucleotide manufacturing
• Working in collaboration with the Internal Manufacturing team during process transfer
• Participating in cross-functional teams and training to gain familiarity in all stages of oligonucleotide research and manufacturing

You are a skilled and self-motivated individual who can optimize and implement processes for synthesizing and purifying complex oligonucleotides. You can operate in a fast-paced environment, troubleshoot instruments, and document operations independently and as part of a team. You will have the opportunity to organize and present results within the group and interface with other teams, so strong communication skills are critical.

You enjoy overcoming challenges in collaboration with colleagues.

Tessera employees are creative and collaborative problem solvers. They have a strong sense of integrity and unwavering commitment to scientific excellence.

Cody Pasko – Senior Scientist, Oligo Foundry

Cody obtained a Masters in Chemistry at Michigan State University, focusing on organometallic catalysis. He has over 9 years of experience working at CROs and CDMOs, most recently being Nitto Avecia where he served as a project lead in the oligonucleotide process development group. At Tessera, he leads a team involved in the development and production of oligonucleotide drug substances, both internally and externally.

Ben Hoogheem – Senior Director, Head of Talent Management

As Head of Talent Management at Tessera Therapeutics, Ben leads Tessera’s talent strategy across talent acquisition, performance management, and talent mobility.

Ben began his career as an in vivo Pharmacologist, which gave him a lasting appreciation for the rigor, creativity, and collaboration that drive scientific discovery. That foundation continues to shape how he helps build organizations designed to enable science thrive.

Ben is focused on aligning exceptional people with bold science – creating the structure, clarity, and culture that empower teams to scale effectively and achieve meaningful impact.

The stated base salary range represents Tessera’s good-faith estimate for this role. Actual compensation will be determined based on a number of factors, including but not limited to individual qualifications, years of relevant experience, internal compensation alignment, and external market data.

Tessera offers a competitive package of base and incentive compensation as well as a comprehensive benefits program designed to support the health, wellness, and financial security of our employees and their families. Benefits currently include group medical, vision, and dental coverage; group life and disability insurance; a 401(k) plan with company contribution; tuition reimbursement; and more.

• group medical, vision, and dental coverage
• group life and disability insurance
• a 401(k) plan with company contribution
• tuition…