Director, LNP Discovery

Overview

CRISPR Therapeutics is seeking an individual with deep expertise in the RNA delivery space to lead our mRNA delivery efforts. Reporting to the Head of Translational Biology, the role will oversee the development of novel LNP (lipid nanoparticle) systems for extrahepatic delivery. The successful candidate will work in a fast-paced Biotech environment and demonstrate strong leadership, collaboration, and communication skills.

• Oversee the development of novel LNPs (lipid chemistry, composition, formulation process).
• Oversee the development of cell-based assays and animal models for LNP testing.
• Lead LNP delivery biology efforts, including protein design and bioconjugation to optimize LNPs.
• Collaborate cross-functionally with pharmacology and programming teams to achieve key milestones.
• Drive the company’s RNA extrahepatic delivery strategy, with emphasis on IP and key deliverables.
• Stay up to date on RNA delivery literature and prepare technical reports and white papers.
• Prepare technical documents and manuscripts for IP filings and publications.
• Present scientific findings internally and externally at key scientific conferences and industry events.

• PhD in Pharmaceutical Sciences, Biochemistry, Engineering, Chemistry, or related field.
• 10+ years of experience with lipid nanoparticles, siRNA, and protein design.
• Demonstrated experience translating animal models from mouse to non-human primate.
• Excellent communication skills (oral and written).
• Track record of innovation in LNP research, spanning bioconjugation, protein design and/or binder design.
• Strict record keeping skills (eLn).
• Proven team leader with a track record of strong research team leadership.
• Ability to synthesize inputs and make strategic recommendations in LNP research.
• Ability to operate effectively in both detailed and high-level settings; strong strategic influence.
• Ownership mindset with proactive problem solving.

• Biotech industry experience.
• Knowledge of the drug development process.
• Collaborative mindset and sense of urgency in solving problems.

Director, LNP Discovery:
Base pay range of $195,000 to $215,000 plus bonus, equity and benefits. The range provided is CRISPR Therapeutics’ reasonable estimate of base compensation. Actual amount will be based on experience, training, skills, and abilities. Some positions require on-site work at manufacturing and lab facilities.

CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person’s race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.

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