Senior Scientist, R&D - Assay Development

Senior Scientist, R&D

Hims & Hers is seeking a Senior Scientist, R&D to join our growing laboratory organization. This individual contributor will report to the Director of R&D and work closely to develop and validate diagnostic assays supporting both traditional and at-home testing programs, and support assay implementation into clinical operations. The ideal candidate is bench-strong, with hands-on experience across the full assay development lifecycle - from feasibility and optimization through verification and validation;

and thrives in a fast-moving, early-stage environment. This is an on-site laboratory role based in Central New Jersey.

Assay Development and Validation

• Design and execute immunoassay development, optimization, and verification studies including ELISA, chemiluminescent, and multiplex formats
• Perform method validation experiments including precision, accuracy, linearity, interference, and stability testing per established protocols
• Apply Design of Experiments (DOE) and statistical methodologies to assay optimization and troubleshooting
• Support LC-MS/MS method development and validation for clinical chemistry and hormone analytes
• Evaluate performance characteristics of capillary versus venous specimens, investigate interference, and develop strategies to extend sample stability
• Develop and revise SOPs to support consistent, reproducible laboratory operations
• Prepare validation summaries, protocols, and technical reports in compliance with quality and regulatory standards

Laboratory Execution

• Perform hands-on laboratory testing using specimens collected via at-home devices such as Tasso and Your Bio Health, including whole blood, plasma, serum, and other biological matrices
• Operate LC-MS/MS instrumentation (SCIEX 4500MD or equivalent) including sample preparation, method validation, and data review
• Support testing on automated chemistry and hematology platforms including Roche Cobas Pro and Sysmex systems, including CBC and whole blood analyte workflows
• Support liquid handling automation workflows for sample processing and high-throughput laboratory operations
• Troubleshoot assay performance issues across immunoassay, clinical chemistry, mass spectrometry, and molecular diagnostic platforms

Data Analysis

• Analyze experimental data and perform statistical evaluation of assay performance including precision, bias, and total allowable error modeling
• Prepare figures, tables, and technical summaries for internal review and scientific communication
• Contribute to peer-reviewed publications and scientific conference presentations

Quality and Regulatory Collaboration

• Partner with the Quality team to ensure study designs and documentation meet CAP, CLIA, and applicable regulatory requirements
• Support investigation and resolution of sample rejection issues to improve overall laboratory quality metrics
• Support laboratory inspection readiness and audit preparation activities
• Collaborate with Clinical Laboratory Operations during assay transfer and implementation

• PhD in Clinical Chemistry, Biochemistry, Analytical Chemistry, Molecular Biology, or related field with 4+ years; OR Master's degree with 7+ years; OR Bachelor's degree with 10+ years of relevant bench experience in a diagnostic or clinical laboratory setting
• Demonstrated hands-on experience in immunoassay development including singleplex and multiplex formats
• Experience with LC-MS/MS instrumentation including sample preparation and method validation
• Experience with capillary and venous blood-based specimen types
• Demonstrated experience leading assay validation and verification studies
• Experience applying DOE and statistical methodologies to assay development and optimization
• Proven ability to work independently and drive projects from concept to completion

Preferred

• Experience in a CAP and/or CLIA regulated laboratory environment
• Experience with at-home or point-of-care diagnostic testing programs
• Experience with dried blood spot (DBS) workflows and stability characterization
• Familiarity with emerging biomarker categories relevant to metabolic health, longevity, and consumer wellness testing
• Experience with NGS-based workflows including library preparation and bioinformatics data review

• Competitive salary & equity compensation for full-time roles
• Unlimited PTO, company holidays, and quarterly mental health days
• Comprehensive health benefits including medical, dental & vision, and parental leave
• Employee Stock Purchase Program (ESPP)
• 401k benefits with employer matching contribution
• Offsite team retreats