Senior Payroll GL Accountant

Structure Therapeutics develops life‑changing medicines for patients using advanced structure‑based and computational drug discovery technology. The company’s platform combines the latest advancements in visualization of molecular interactions, computational chemistry, and data integration to design orally available, superior small molecule medicines that overcome current limitations of biologic and peptide drugs. We are advancing a clinical‑stage pipeline of differentiated treatments focused on chronic diseases with high unmet need, including cardiovascular, metabolic, and pulmonary conditions.

Structure Therapeutics is led by an experienced group of international drug innovators and financed by top‑tier global life sciences investors. The company completed an initial public offering (IPO) in February 2023. With offices in California and Shanghai, Structure Therapeutics has the benefit of being at the center of life science innovation in both the US and China and capitalizing on the strengths of each geographic location.

We’re looking for a Senior Payroll/GL Accountant with strong expertise in Payroll and General Ledger (GL) operations to join our Finance team. In this role, you'll take full ownership of the payroll process, act as the primary point of contact for payroll and payroll tax matters and help streamline accounting operations. The ideal candidate brings hands‑on experience in ADP Total Source and Net Suite, thrives in a fast‑paced, high‑growth environment, and is passionate about accuracy, compliance, and process excellence.

• Own the end‑to‑end semi‑monthly payroll process for U.S.
  
  -based employees via ADP Total Source, and coordinate payroll for our EMEA employees with an international payroll provider
• Process off‑cycle payroll, including taxable event reporting for equity transactions (e.g., RSU vesting, stock option exercises, ESPP)
• Monitor and resolve payroll tax issues, ensuring accurate withholding, reporting, and compliance across jurisdictions
• Strengthen internal controls surrounding the payroll process to maintain SOX compliance

• Prepare monthly payroll journal entries, including detailed department and time allocation, ensuring accurate payroll cost distribution across the organization
• Contribute to the monthly period‑end close by reconciling payroll‑related balance sheet accounts and verifying accuracy and completeness

• Review employee expense report coding in Ramp prior to synchronization with Net Suite

• Partner with Finance and HR teams to support the payroll and monthly close process and implement efficiency and accuracy improvements
• Support general ledger tasks, such as preparing cash journal entries, bank account reconciliations, and others as needed
• Coordinate and provide PBC (Prepared by Client) documentation to external auditors in support of SOX testing, quarterly and annual financial audits

Bachelor’s degree in Accounting, Finance, or Business Administration (with an accounting concentration)

• 5+ years of relevant accounting experience, with direct payroll ownership preferred
• Hands‑on experience with ADP Total Source and Net Suite
• Strong knowledge of payroll tax regulations, including multi‑state withholding, equity compensation taxation, and year‑end reporting (e.g., W‑2, 941s)
• Experience with Equity Edge Online and understanding of equity reporting and related payroll tax withholding and compliance requirements
• Proficient in US GAAP and payroll accounting principles; proven experience supporting month‑end close and account reconciliations
• Familiarity with SOX compliance
• Advanced Excel skills a must
• Highly organized, detail‑oriented, and proactive in identifying process improvements
• Excellent communication skills and ability to collaborate cross‑functionally

This position is primarily based in the San Francisco Bay Area and requires little to no travel. Travel may be required on an occasional basis for meetings, training, or company events.

Structure Therapeutics Inc. is an…