Sr. Scientist, Spatial Biology

NOETIK is a frontier therapeutics company harnessing AI to deeply understand human biology and redefine clinical outcomes in oncology. Leveraging the largest proprietary multimodal oncology dataset of its kind, uniquely integrating deep spatial profiling with routine clinical assays, NOETIK’s foundation AI models precisely match therapeutic targets to patient subpopulations and accurately predict clinical efficacy. This AI-first approach elevates therapeutic development from probabilistic guesswork to precision science.

In this role, we are seeking a highly motivated and detail-oriented Senior Scientist to join our team at the frontier of spatial biology and AI, driving hands on execution, protocol development, and quality standards for spatial biology experiments on human tissue samples in a lab built to fuel next-generation AI models. The ideal candidate will have deep hands-on experience with in situ hybridization & proteomics techniques, spatial data analysis and demonstrate strong troubleshooting, mentorship, and organizational skills.

This is an exciting opportunity to contribute to a multidisciplinary laboratory environment at the interface between Spatial Biology and AI model generation.

Aswescaleupourdatagenerationengine,thisroleisfocusedondrivingimpactthroughday-to-dayexecution,troubleshooting,andqualityenforcementacrossahighvolumeofruns.

• Independently plan,performandtroubleshootspatialbiologyexperimentsonhumantissuesamples.
• Collaboratecloselywithcross-functionalteamsincluding
  
  Histology,and Scientific
  
  Operationstoensureseamlessprojectexecution.
• Activelyparticipateinlabteammeetings,fosteringacollaborativeandinnovation-driven culture.
• Leadcross-functionalprojectswith
  
  EngineeringandMLTeammemberstodesignthenextgenerationofdataforAImodeltraining.

• PhDinmolecularbiology,genomics,cell biology,biomedical engineering,orarelatedfield.
• 2-5+yearsofindustryhands-onexperiencewithspatialtranscriptomics(Cos Mx,Xenium,MERFISH…);direct
  
  CosMxexperiencestronglypreferred.
• Experiencewithspatialproteomicsplatforms(e.g.,Cos Mx Protein ,Akoya Pheno Cycler ,Lunaphore..)andimmunofluorescencepaneldesignarehighlydesirable.
• Provenabilitytoindependentlytroubleshootwet-labandimaging-basedassayfailures,tracingissuesbacktorootcause.
• Solid knowledge of spatial transcriptomics data QC metrics: transcript count distributions, segmentation quality, dropout/housekeeping-gene diagnostics, batch effects, and spatial artifacts.
• Comfortableenforcingstandardsacrossateamthatincludesbothjuniorandmoreseniorcolleagues—thisrolerequiresleadershipaswellastechnicalskill.
• Excellent organizational,communication(oralandwritten),anddocumentationskills.

• Familiaritywithcancertissuebiologyandidentitymarkerpanels.
• Proficiency with Pythonor Rfordataanalysis .
• Priorexperiencementoringorinformallyleadingjuniorlabstaff.

Great science is a team sport. We are focused on creating a culture where brilliant people from different backgrounds can solve hard problems together. At Noetik, culture isn't just about perks; it’s about building a vibrant, collaborative community where everyone has the tools and the autonomy to thrive.

Location &

Collaboration:

our primary lab and office space is located in South San Francisco. We operate as a hybrid organization
, utilizing Slack, Zoom, and a modern tech stack to stay seamlessly connected regardless of time zone.

Intentional Connection: we believe that high-impact work requires intentional time together. We keep the team aligned through monthly All-Hands meetings and Quarterly Co-working Weeks at our South San Francisco office. Once a year, we gather for an Annual Reset - a week-long offsite dedicated to high-level strategy, collaboration and team bonding.…