Director, R&D FP&A South San Francisco, CA

The Position

We are seeking a Director, FP&A to serve as a strategic finance partner to our R&D organization. In this highly visible role, you will support critical investment decisions across our development portfolio by delivering financial insights, forecasting, and decision support.

We’ll work closely with R&D and finance leadership to translate scientific and clinical strategies into actionable financial plans, helping ensure resources are deployed effectively across programs.

This role reports to the Sr. Director of FP&A and follows a hybrid schedule of two-to-three days per week in office.

Strategic Partnership & Decision Support

• Partner with R&D leadership and project teams to develop portfolio and program-level financial plans
• Lead scenario modeling, cost-benefit analyses, and vendor investment decisions
• Support clinical program investment decisions and other high-priority strategic initiatives

Financial Planning & Analysis

• Deliver accurate and timely forecasts, budgets, and long-range plans for R&D functions
• Prepare and present financial analyses to senior leadership, including materials for Board meetings
• Provide variance analysis and actionable insights to inform decision-making

Cross-Functional Collaboration

• Partner closely with Accounting to align budget vs actuals, including accruals, coding, and variance reporting
• Collaborate with functional stakeholders to translate scientific and operational plans into financial outcomes

Process Improvement & Systems

• Drive improvements in FP&A processes, reporting, and forecasting accuracy
• Partner with the Head of FP&A to enhance and automate allocation methodologies across programs and indications

As a Director, we also expect our leaders to demonstrate the following Leadership

Competencies:

• Communication and Influence
  • Builds communication channels across Maze for sharing information.
  • Influences Senior Management decisions through persuasive arguments.
  • Respectfully addresses differing opinions leading to support of decisions.
• Teamwork and Collaboration
  • Champions partnerships and connections across Maze.
  • Proactively addresses issues that could result in breakdown of team relationships.
  • Spotlights team and individual contributions in public forums.
• Execution and Results
  • Addresses gaps and leverages strengths to get best results.
  • Maintains a steadying presence and clarifies priorities during change.
  • Anticipates and removes barriers that put functional/corporate goals at risk.
• Develop Others and Self
  • Remove barriers to staff development and empowers them to make their own decisions.
  • Stays current on industry trends and keeps direct-reports prepared and responsive.

• Bachelor’s degree in Finance, Accounting, Economics, or related field; MBA or equivalent experience preferred.
• 10+ years of experience in the pharmaceutical or biotech industry, including significant FP&A experience
• Experience supporting R&D or development organizations strongly preferred
• Clinical trial forecasting and accruals experience preferred

• Advanced proficiency in Excel and Power Point
• Experience with financial systems such as Net Suite, Coupa, and Anaplan, or similar tools
• Strong financial modeling and forecasting capabilities, including ad hoc analysis

• Proven ability to build strong relationships and influence cross-functional stakeholders
• Ability to translate complex scientific and strategic concepts into clear financial insights
• Excellent written and verbal communication

• Highly organized with the ability to manage multiple priorities and meet deadlines
• Detail-oriented and solution-driven, with a focus on continuous improvement
• Collaborative mindset with a focus on improving efficiency and effectiveness
• Interest in exploring applications of AI to enhance FP&A processes

This role follows a hybrid schedule, with an expectation to be onsite at our South San Francisco headquarters two-to-three days per week.

About Maze Therapeutics

Maze Therapeutics is a clinical-stage biopharmaceutical company harnessing human genetics to develop precision medicines for patients with…