Computational Scientist II

Overview

The Fountain Group is currently seeking a Computational Scientist II for a prominent client of ours.

Title:

Quality Engineer II

Location:

South San Francisco, CA

Duration: 01 Year (With Possible Extension/Hire)

Pay: $42-$47/ hours

Shift

Hours:

Standard Shift

At Genentech's Developmental Sciences (Dev Sci) organization, we are transforming how quantitative drug development is conducted through the integration of AI and agentic workflows. Our Clinical Pharmacology and Pharmacometrics (CPP) group is at the forefront of this effort, embedding large language model (LLM)-powered tools directly into pharmacometric workflows to accelerate scientific planning, analysis, and decision‑making.

• Build and Deploy Agentic LLM Workflows
• Design and implement LLM agent‑based pipelines that automate or augment complex scientific workflows within the CPP group.
• Develop human‑in‑the‑loop systems that allow scientists to collaborate with AI tools through natural language, iterative feedback, and structured outputs.
• Integrate domain‑specific context — such as internal guidelines, templates, and scientific reference materials — into LLM workflows to ensure outputs meet scientific and regulatory standards.
• Package reusable LLM workflow components and libraries, and ensure tools are production‑ready, well‑documented, and accessible to scientist users with varying technical backgrounds.
• Develop Quality and Evaluation Infrastructure
• Build automated quality control layers to evaluate LLM outputs against structural, scientific, and consistency criteria.
• Design evaluation frameworks to measure output quality, efficiency gains, and failure modes over time.
• Maintain versioned evaluation logs and contribute to periodic reports supporting tool improvement and stakeholder communication.
• Collaborate and Innovate
• Work closely with pharmacometricians, data scientists, and automation engineers to understand scientific requirements and translate them into robust system designs.
• Stay current with advances in LLM tooling, agentic frameworks, and AI applications in drug development and R&D.
• Contribute to the broader Dev Sci AI adoption by sharing learnings and best practices across functions as well as providing trainings.

• You hold or are pursuing a Master's or PhD degree in a quantitative or computational field, such as Computer Science, Data Science, Bioinformatics, Computational Biology, Pharmaceutical Sciences, or a related discipline. OR BA/BS w/ 5 years min exp
• Domain Knowledge
• Familiarity with the drug development or pharmaceutical R&D context is strongly preferred. Candidates with an awareness of clinical development processes, quantitative sciences, or life sciences research — and a genuine interest in applying AI to advance drug development — will thrive in this role.

• Solid software engineering experience and familiarity with standard development practices — version control (Git), code review, documentation, and working effectively within collaborative codebases are expected. Comfortable working with structured and unstructured data, and able to pick up new tools and frameworks quickly.
• Prior exposure to LLM applications is a big plus — whether through building and deploying LLM‑powered pipelines, working with agentic frameworks such as Lang Smith, retrieval‑augmented generation (RAG) architectures, harness engineering or guardrail design, or integrating LLM APIs into functional tools.
• Familiarity with cloud platforms (AWS, GCP, or Azure) and a portfolio of relevant projects are also welcomed.

• Collaborative and communicative — able to bridge engineering and scientific perspectives and explain technical decisions clearly.
• Self‑directed and ownership‑oriented, with a track record of delivering in ambiguous or evolving project environments.
• Curious and motivated by the intersection of AI technology and real‑world scientific impact.

This is a meaningful opportunity to shape how AI is applied to one of the most knowledge‑intensive processes in drug development. You'll have real ownership over the tools you build and direct collaboration with the scientists who rely on them — contributing to greater efficiency, consistency, and scientific quality across the CPP group and beyond.