Information Technology Infrastructure Manager

This role will be based out of South San Francisco, California, and reports to the Director, IT Infrastructure & Operations.

The individual in this role serves as the internal technical expert for Lyell's infrastructure, cloud, identity, and collaboration environments. This is a hands‑on individual contributor role responsible for the configuration, implementation, and ongoing operation of these platforms in partnership with Lyell's managed service provider (MSP). Acting as the bridge between business requirements and infrastructure, this person translates stakeholder needs into scalable, compliant solutions and ensures Lyell operates reliable, validated infrastructure in a regulated life sciences environment.

• Design and build infrastructure across cloud (AWS), on‑premises, networking, identity, and collaboration platforms in line with best practices, industry standards, and Lyell’s technology strategy.
• Translate approved architectures and designs into detailed configurations and implementation plans; execute builds and changes, validate against requirements, and hand off steady‑state operations to the MSP while retaining configuration and implementation ownership.
• Provide key technical input and feedback into architecture standards, infrastructure strategy, and roadmap planning led by IT leadership — drawing on hands‑on knowledge of platform capabilities, constraints, and operational realities — and maintain up‑to‑date documentation of systems configuration and project status.
• Own the configuration, operation, and optimization of Lyell’s AWS environment — implementing governance, cost management, and security controls per defined standards and identifying opportunities to optimize and maximize the value of Lyell’s infrastructure investment.
• Configure and maintain on‑premises server and network systems, including VMware vSphere clusters, Windows Server, Active Directory, and network platforms (Juniper, Cisco Meraki, Palo Alto Networks) spanning routing, switching, firewall policy, and segmentation.
• Ensure backup and disaster recovery integrity (e.g., Veeam), including monitoring backup health and resolving exceptions, and manage VPN, and telecommunications infrastructure.
• Own the configuration, and governance of Okta, Microsoft 365, Zoom, and Slack as core infrastructure platforms, ensuring identity, access, and collaboration systems meet security, audit, and compliance requirements (e.g., access reviews, joiner/mover/leaver, audit logging).
• Support lab infrastructure, including associated software and attached instrumentation.
• Serve as primary day‑to‑day contact and technical authority over the MSP: define scope, review performance against SLAs, oversee implementation to ensure adherence to defined architecture, and ensure service delivery aligns with ITIL practices (incident, problem, change, and request management).
• Act as the Tier 3 escalation point for the service desk, personally resolving complex or time‑sensitive infrastructure incidents during business hours and providing guidance to service desk staff on end‑user computing systems.
• Participate in vendor evaluations, SOW reviews, supplier and hosted‑solution oversight, and ongoing contract governance.
• Own security tooling configuration per confirmed architecture (EDR, SIEM, and related platforms), and partner with the validation team on computer system validation (CSV) to ensure infrastructure designs support compliant, audit‑ready operations and SOX and GxP audit activities.
• Own the configuration, administration, and governance of Lyell’s enterprise AI platforms — primarily Anthropic Claude — including user provisioning and access controls, workspace and policy configuration, integration with identity and collaboration systems, and usage monitoring, while partnering with compliance teams to ensure responsible, audit‑ready use that meets the company’s data‑protection and regulatory requirements.

• BA/BS in an information technology field, or equivalent experience, with a minimum of 10 years in IT infrastructure, including 8+ years of hands‑on solution architecture,…